FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056569376> ?p ?o ?g. }

• W2056569376 endingPage "104" @default.
• W2056569376 startingPage "97" @default.
• W2056569376 abstract "The three randomised controlled trials, Interventional Management of Stroke III (IMS3), Mechanical Retrieval and Revascularization of Stroke Clots Using Embolectomy (MR RESCUE) and Synthesis Expanasion: A Randomized Controlled Trial on Intra-Arterial Versus Intravenous Thrombolysis in Acute Ischaemic Stroke (SYNTHESIS EXP) showed no significant difference in clinical outcomes comparing intra-arterial (IA) therapy with intravenous thrombolysis. This article will explore the reasons for failure to show superiority of IA therapy.There are many reasons for the disappointing results of the three randomised controlled trials. Opposing views on IA therapy exist. Critics argue that only a small percentage of patients will be eligible for IA therapy and that it will never be cost-effective. Additionally, current trials have failed to address superior recanalization rates of new generation devices and lack of patient selection by advanced imaging. Time-to-treatment is longer in these randomised controlled trials and stroke outcomes were worse than anticipated. The current randomised controlled trials also took long periods to complete. There is emerging evidence that general anesthetic negatively influences outcome. Next generation trials will attempt to address these issues. Key Messages: There are disparate explanations for the disappointing results from the three IA therapy randomized controlled studies. Poor recanalisation rates with first generation endovascular devices, lack of advanced neuroimaging to aid in patient selection, lack of data surrounding the use of general anaesthesia, and prolonged time-to-treatment are potential contributors to negative results. The new generation of trials has the potential of addressing these pressing issues." @default.
• W2056569376 created "2016-06-24" @default.
• W2056569376 creator A5019133381 @default.
• W2056569376 creator A5030100496 @default.
• W2056569376 date "2013-01-01" @default.
• W2056569376 modified "2023-10-13" @default.
• W2056569376 title "Future Directions for Intra-Arterial Therapy for Acute Ischaemic Stroke: Is There Life after Three Negative Randomized Controlled Studies?" @default.
• W2056569376 cites W1971167348 @default.
• W2056569376 cites W1983567452 @default.
• W2056569376 cites W1986233455 @default.
• W2056569376 cites W1990453642 @default.
• W2056569376 cites W1990814258 @default.
• W2056569376 cites W2002351581 @default.
• W2056569376 cites W2009566871 @default.
• W2056569376 cites W2014796100 @default.
• W2056569376 cites W2020303089 @default.
• W2056569376 cites W2028962802 @default.
• W2056569376 cites W2029618616 @default.
• W2056569376 cites W2031591759 @default.
• W2056569376 cites W2032622475 @default.
• W2056569376 cites W2036653122 @default.
• W2056569376 cites W2046373516 @default.
• W2056569376 cites W2048836694 @default.
• W2056569376 cites W2055940399 @default.
• W2056569376 cites W2080196819 @default.
• W2056569376 cites W2099706007 @default.
• W2056569376 cites W2106199025 @default.
• W2056569376 cites W2111559905 @default.
• W2056569376 cites W2114603310 @default.
• W2056569376 cites W2127483237 @default.
• W2056569376 cites W2133514192 @default.
• W2056569376 cites W2139363863 @default.
• W2056569376 cites W2139703299 @default.
• W2056569376 cites W2146122787 @default.
• W2056569376 cites W2152667095 @default.
• W2056569376 cites W2314073431 @default.
• W2056569376 cites W2326133719 @default.
• W2056569376 cites W88393610 @default.
• W2056569376 doi "https://doi.org/10.1159/000356087" @default.
• W2056569376 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4062314" @default.
• W2056569376 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25187785" @default.
• W2056569376 hasPublicationYear "2013" @default.
• W2056569376 type Work @default.
• W2056569376 sameAs 2056569376 @default.
• W2056569376 citedByCount "7" @default.
• W2056569376 countsByYear W20565693762015 @default.
• W2056569376 countsByYear W20565693762016 @default.
• W2056569376 countsByYear W20565693762019 @default.
• W2056569376 countsByYear W20565693762020 @default.
• W2056569376 countsByYear W20565693762022 @default.
• W2056569376 crossrefType "journal-article" @default.
• W2056569376 hasAuthorship W2056569376A5019133381 @default.
• W2056569376 hasAuthorship W2056569376A5030100496 @default.
• W2056569376 hasBestOaLocation W20565693761 @default.
• W2056569376 hasConcept C126322002 @default.
• W2056569376 hasConcept C127413603 @default.
• W2056569376 hasConcept C141071460 @default.
• W2056569376 hasConcept C164705383 @default.
• W2056569376 hasConcept C168563851 @default.
• W2056569376 hasConcept C177713679 @default.
• W2056569376 hasConcept C2776265017 @default.
• W2056569376 hasConcept C2776652129 @default.
• W2056569376 hasConcept C2779464278 @default.
• W2056569376 hasConcept C2779581417 @default.
• W2056569376 hasConcept C2780645631 @default.
• W2056569376 hasConcept C500558357 @default.
• W2056569376 hasConcept C535046627 @default.
• W2056569376 hasConcept C71924100 @default.
• W2056569376 hasConcept C78519656 @default.
• W2056569376 hasConceptScore W2056569376C126322002 @default.
• W2056569376 hasConceptScore W2056569376C127413603 @default.
• W2056569376 hasConceptScore W2056569376C141071460 @default.
• W2056569376 hasConceptScore W2056569376C164705383 @default.
• W2056569376 hasConceptScore W2056569376C168563851 @default.
• W2056569376 hasConceptScore W2056569376C177713679 @default.
• W2056569376 hasConceptScore W2056569376C2776265017 @default.
• W2056569376 hasConceptScore W2056569376C2776652129 @default.
• W2056569376 hasConceptScore W2056569376C2779464278 @default.
• W2056569376 hasConceptScore W2056569376C2779581417 @default.
• W2056569376 hasConceptScore W2056569376C2780645631 @default.
• W2056569376 hasConceptScore W2056569376C500558357 @default.
• W2056569376 hasConceptScore W2056569376C535046627 @default.
• W2056569376 hasConceptScore W2056569376C71924100 @default.
• W2056569376 hasConceptScore W2056569376C78519656 @default.
• W2056569376 hasIssue "3" @default.
• W2056569376 hasLocation W20565693761 @default.
• W2056569376 hasLocation W20565693762 @default.
• W2056569376 hasLocation W20565693763 @default.
• W2056569376 hasLocation W20565693764 @default.
• W2056569376 hasLocation W20565693765 @default.
• W2056569376 hasOpenAccess W2056569376 @default.
• W2056569376 hasPrimaryLocation W20565693761 @default.
• W2056569376 hasRelatedWork W1562254956 @default.
• W2056569376 hasRelatedWork W1979533557 @default.
• W2056569376 hasRelatedWork W2005922890 @default.
• W2056569376 hasRelatedWork W2025707641 @default.
• W2056569376 hasRelatedWork W2035395325 @default.
• W2056569376 hasRelatedWork W2044548821 @default.

• next