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- W2056570664 abstract "Overactive bladder is a common and distressing disorder that imposes significant financial and quality-of-life costs. The current therapeutic paradigm aims to decrease detrusor overactivity via blockade of bladder M3 muscarinic receptors, the primary cholinergic receptors responsible for detrusor contraction. However, systemic antimuscarinic adverse effects, such as dry mouth and constipation, limit the tolerability of antimuscarinic treatment. Therefore, a uroselective M3 receptor antagonist would be considered optimal therapy for overactive bladder. Darifenacin (Enablex®) is the most recent antimuscarinic drug approved for the treatment of overactive bladder. It demonstrates M3 receptor selectivity, but is not M3 specific. Despite animal data suggesting uroselectivity, it is not sufficiently uroselective in therapeutic use. While effective in reducing symptoms related to overactive bladder, dry mouth and constipation remain common. There are no comparative trials comparing darifenacin with existing agen..." @default.
- W2056570664 created "2016-06-24" @default.
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- W2056570664 date "2006-11-01" @default.
- W2056570664 modified "2023-09-26" @default.
- W2056570664 title "Darifenacin: a selective M3muscarinic receptor antagonist for the treatment of overactive bladder" @default.
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- W2056570664 doi "https://doi.org/10.2217/14750708.3.6.723" @default.
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