FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056570718> ?p ?o ?g. }

• W2056570718 endingPage "15911" @default.
• W2056570718 startingPage "15903" @default.
• W2056570718 abstract "The c-Jun N-terminal kinase (JNK) mitogen-activated protein kinase (MAPK) signaling pathway mediates stress responses in cells. JNK activity is regulated by a protein kinase cascade consisting of a MAPK kinase (MKK) and a MAPK kinase kinase (MAPKKK). beta-Arrestin-2 acts as a scaffold by directly binding to the JNK3 isoform and also by recruiting MKK4 and the MAPKKK apoptosis-signaling kinase-1 (ASK1). In this study, we demonstrate by co-precipitation that the extended N-terminal region of JNK3 mediates binding to the C terminus of beta-arrestin-2 and that the N terminus of JNK3 is required for its activation via beta-arrestin-2. We have used site-specific mutagenesis to identify key residues within the N terminus of JNK3 that are essential for binding and demonstrate that this region represents an independent beta-arrestin-2 binding motif that can be fused to other MAPKs and permit their recruitment to the scaffold complex. In addition, we demonstrate that JNK3 recruits MKK4 to the beta-arrestin-2 scaffold complex by binding to the MAPK docking domain (D-domain) located within the N terminus of MKK4. These findings uncover molecular determinants of beta-arrestin-2 scaffold complex assembly and assign a previously unrecognized role for the unique extended N terminus of JNK3." @default.
• W2056570718 created "2016-06-24" @default.
• W2056570718 creator A5032186368 @default.
• W2056570718 creator A5078982842 @default.
• W2056570718 date "2008-06-01" @default.
• W2056570718 modified "2023-10-12" @default.
• W2056570718 title "The β-Arrestin-2 Scaffold Protein Promotes c-Jun N-terminal Kinase-3 Activation by Binding to Its Nonconserved N Terminus" @default.
• W2056570718 cites W1530284699 @default.
• W2056570718 cites W1572174728 @default.
• W2056570718 cites W1967218150 @default.
• W2056570718 cites W1976519846 @default.
• W2056570718 cites W1982926119 @default.
• W2056570718 cites W1984875486 @default.
• W2056570718 cites W1998977808 @default.
• W2056570718 cites W2000500986 @default.
• W2056570718 cites W2002300983 @default.
• W2056570718 cites W2002879408 @default.
• W2056570718 cites W2008297774 @default.
• W2056570718 cites W2011659866 @default.
• W2056570718 cites W2012571494 @default.
• W2056570718 cites W2021202712 @default.
• W2056570718 cites W2026951979 @default.
• W2056570718 cites W2034247990 @default.
• W2056570718 cites W2036662476 @default.
• W2056570718 cites W2056415191 @default.
• W2056570718 cites W2061699263 @default.
• W2056570718 cites W2068251639 @default.
• W2056570718 cites W2076485183 @default.
• W2056570718 cites W2079193109 @default.
• W2056570718 cites W2083117403 @default.
• W2056570718 cites W2104836622 @default.
• W2056570718 cites W2109659042 @default.
• W2056570718 cites W2120664225 @default.
• W2056570718 cites W2130632774 @default.
• W2056570718 cites W2132108032 @default.
• W2056570718 cites W2149789552 @default.
• W2056570718 cites W2155158959 @default.
• W2056570718 cites W2155483393 @default.
• W2056570718 cites W2162368656 @default.
• W2056570718 cites W4313635391 @default.
• W2056570718 doi "https://doi.org/10.1074/jbc.m710006200" @default.
• W2056570718 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3259632" @default.
• W2056570718 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18408005" @default.
• W2056570718 hasPublicationYear "2008" @default.
• W2056570718 type Work @default.
• W2056570718 sameAs 2056570718 @default.
• W2056570718 citedByCount "46" @default.
• W2056570718 countsByYear W20565707182012 @default.
• W2056570718 countsByYear W20565707182013 @default.
• W2056570718 countsByYear W20565707182014 @default.
• W2056570718 countsByYear W20565707182015 @default.
• W2056570718 countsByYear W20565707182016 @default.
• W2056570718 countsByYear W20565707182017 @default.
• W2056570718 countsByYear W20565707182018 @default.
• W2056570718 countsByYear W20565707182019 @default.
• W2056570718 countsByYear W20565707182020 @default.
• W2056570718 countsByYear W20565707182022 @default.
• W2056570718 countsByYear W20565707182023 @default.
• W2056570718 crossrefType "journal-article" @default.
• W2056570718 hasAuthorship W2056570718A5032186368 @default.
• W2056570718 hasAuthorship W2056570718A5078982842 @default.
• W2056570718 hasBestOaLocation W20565707182 @default.
• W2056570718 hasConcept C124160383 @default.
• W2056570718 hasConcept C137361374 @default.
• W2056570718 hasConcept C159479382 @default.
• W2056570718 hasConcept C184235292 @default.
• W2056570718 hasConcept C185592680 @default.
• W2056570718 hasConcept C53645450 @default.
• W2056570718 hasConcept C59143045 @default.
• W2056570718 hasConcept C62478195 @default.
• W2056570718 hasConcept C82495950 @default.
• W2056570718 hasConcept C86803240 @default.
• W2056570718 hasConcept C90934575 @default.
• W2056570718 hasConcept C95444343 @default.
• W2056570718 hasConcept C97029542 @default.
• W2056570718 hasConcept C99405784 @default.
• W2056570718 hasConceptScore W2056570718C124160383 @default.
• W2056570718 hasConceptScore W2056570718C137361374 @default.
• W2056570718 hasConceptScore W2056570718C159479382 @default.
• W2056570718 hasConceptScore W2056570718C184235292 @default.
• W2056570718 hasConceptScore W2056570718C185592680 @default.
• W2056570718 hasConceptScore W2056570718C53645450 @default.
• W2056570718 hasConceptScore W2056570718C59143045 @default.
• W2056570718 hasConceptScore W2056570718C62478195 @default.
• W2056570718 hasConceptScore W2056570718C82495950 @default.
• W2056570718 hasConceptScore W2056570718C86803240 @default.
• W2056570718 hasConceptScore W2056570718C90934575 @default.
• W2056570718 hasConceptScore W2056570718C95444343 @default.
• W2056570718 hasConceptScore W2056570718C97029542 @default.
• W2056570718 hasConceptScore W2056570718C99405784 @default.
• W2056570718 hasIssue "23" @default.
• W2056570718 hasLocation W20565707181 @default.
• W2056570718 hasLocation W20565707182 @default.
• W2056570718 hasLocation W20565707183 @default.
• W2056570718 hasLocation W20565707184 @default.
• W2056570718 hasOpenAccess W2056570718 @default.
• W2056570718 hasPrimaryLocation W20565707181 @default.
• W2056570718 hasRelatedWork W1487918137 @default.

• next