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- W2056570737 abstract "Medlar (1, 2) and Lane (3), were the first to study the pathogenicity of the Phialophora verrucosa. Medlar made inoculations in guinea pigs, rats and mice. He states: fungus is not pathogenic for the guinea pig, it produces only a non-progressive reaction type foreign body. Unfortunately, Medlar did not give the route of the inoculation, the time of observation and the kind of material inoculated. Reporting his experimentation with rats and mice, Medlar states that by means of peritoneal inoculation in these animals he was able to produce tubercles in the peritoneum (4—6 weeks). These tubercies showed a histological picture of the typical granuloma. He also obtained retroculture of the fungus. In his inoculations of rats and mice by the subdural method he could produce, after 6—10 weeks, an abscess from which the fungus was isolated. He did not specify the exact nature of the material which was inoculated. Lane (3), states that the fungus is not pathogenic for the guinea pig. In mice and rats, he succeeded in producing peritoneal tubercles and skin lesions similar to those found in man. He failed to specify the exact nature of the material used for inoculation. In Brazil, the first published work was that of Alexandrono Pedroso and J. M. Gomes (4). They inoculated pus in guinea pigs and rabbits peritoneally and subcutaneously, without positive results. These investigators also inoculated rats with a suspension of their culture which was 17 days old. They noted only the development of small nodules which were soon reabsorbed. In 1927, Montpellier and Catanei (5) inoculated subcutaneously their new species, Hormodendrum Algeriensis (today known as Fonsecaea Pedrosoi) in rabbits. An abscess in which there were spores and myceia was produced at the point of inoculation. The retroculture was positive. They also made intravenous inoculations in pigeons and peritoneal inoculations in rats, but the results were negative. In 1929, Gomes and Pessoa (6), in Brazil, inoculated dogs, rabbits and monkeys with their fungus. In one dog and one rabbit some warts appeared which fell off spontaneously. The retrocultures were negative." @default.
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- W2056570737 date "1945-10-01" @default.
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- W2056570737 title "Experimental Studies on Chromoblastomycosis" @default.
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- W2056570737 doi "https://doi.org/10.1038/jid.1945.26" @default.
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