FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056570827> ?p ?o ?g. }

• W2056570827 endingPage "177" @default.
• W2056570827 startingPage "168" @default.
• W2056570827 abstract "Z-ligustilide (LIG), the main lipophilic component of Radix Angelica sinensis, has been shown to protect against brain ischemic damage in rodents by oral and intra-peritoneal treatments. The present study aimed to confirm the therapeutic effect of LIG administered intravenously on 2 h middle cerebral artery occlusion (MCAO) and 22 h reperfusion injury in rats since oral administration has low bioavailability, slow absorption and distribution. Moreover, whether LIG activated the NF-E2-related factor 2/ heme oxygenase-1 (Nrf2/HO-1) pathway was also investigated in vivo and in vitro to further elucidate the precise protective mechanisms. In vivo, rats treated intravenously with LIG immediately after the surgery was finished had less neurological dysfunction and smaller infarct volume than that of the vehicle-treated rats. Additionally, LIG promoted Nrf2 nuclear translocation, and further remarkably increased Nrf2 and HO-1 protein expression. In vitro, LIG induced Nrf2 nuclear translocation and up-regulated HO-1 expression in a time-dependent and concentration-dependent manner. Furthermore, LIG treatment reduced cell death induced by OGD, however, the protective action was abolished while Nrf2/HO-1 expression was knockdown by RNA interference. These results noted that intravenous post-treatment with LIG exhibits noticeable neuroprotective properties against brain damage by ischemia–reperfusion and the ability of LIG to activate Nrf2/HO-1 pathway may be partly responsible for it." @default.
• W2056570827 created "2016-06-24" @default.
• W2056570827 creator A5014838642 @default.
• W2056570827 creator A5021376490 @default.
• W2056570827 creator A5042041170 @default.
• W2056570827 creator A5045580230 @default.
• W2056570827 creator A5049132248 @default.
• W2056570827 creator A5053695034 @default.
• W2056570827 creator A5070530669 @default.
• W2056570827 date "2013-07-01" @default.
• W2056570827 modified "2023-10-15" @default.
• W2056570827 title "Z-ligustilide activates the Nrf2/HO-1 pathway and protects against cerebral ischemia–reperfusion injury in vivo and in vitro" @default.
• W2056570827 cites W1486915017 @default.
• W2056570827 cites W1584771014 @default.
• W2056570827 cites W1974494901 @default.
• W2056570827 cites W1981958496 @default.
• W2056570827 cites W1990141059 @default.
• W2056570827 cites W1994724497 @default.
• W2056570827 cites W2011243629 @default.
• W2056570827 cites W2011665108 @default.
• W2056570827 cites W2021117496 @default.
• W2056570827 cites W2037335064 @default.
• W2056570827 cites W2041868208 @default.
• W2056570827 cites W2043336768 @default.
• W2056570827 cites W2045609579 @default.
• W2056570827 cites W2068659488 @default.
• W2056570827 cites W2071871783 @default.
• W2056570827 cites W2075736059 @default.
• W2056570827 cites W2090485914 @default.
• W2056570827 cites W2112505121 @default.
• W2056570827 cites W2117648066 @default.
• W2056570827 cites W2118898883 @default.
• W2056570827 cites W2122020125 @default.
• W2056570827 cites W2122891448 @default.
• W2056570827 cites W2144918294 @default.
• W2056570827 doi "https://doi.org/10.1016/j.brainres.2013.05.009" @default.
• W2056570827 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23688544" @default.
• W2056570827 hasPublicationYear "2013" @default.
• W2056570827 type Work @default.
• W2056570827 sameAs 2056570827 @default.
• W2056570827 citedByCount "61" @default.
• W2056570827 countsByYear W20565708272014 @default.
• W2056570827 countsByYear W20565708272015 @default.
• W2056570827 countsByYear W20565708272016 @default.
• W2056570827 countsByYear W20565708272017 @default.
• W2056570827 countsByYear W20565708272018 @default.
• W2056570827 countsByYear W20565708272019 @default.
• W2056570827 countsByYear W20565708272020 @default.
• W2056570827 countsByYear W20565708272021 @default.
• W2056570827 countsByYear W20565708272022 @default.
• W2056570827 countsByYear W20565708272023 @default.
• W2056570827 crossrefType "journal-article" @default.
• W2056570827 hasAuthorship W2056570827A5014838642 @default.
• W2056570827 hasAuthorship W2056570827A5021376490 @default.
• W2056570827 hasAuthorship W2056570827A5042041170 @default.
• W2056570827 hasAuthorship W2056570827A5045580230 @default.
• W2056570827 hasAuthorship W2056570827A5049132248 @default.
• W2056570827 hasAuthorship W2056570827A5053695034 @default.
• W2056570827 hasAuthorship W2056570827A5070530669 @default.
• W2056570827 hasConcept C126322002 @default.
• W2056570827 hasConcept C150903083 @default.
• W2056570827 hasConcept C173396325 @default.
• W2056570827 hasConcept C185592680 @default.
• W2056570827 hasConcept C190283241 @default.
• W2056570827 hasConcept C202751555 @default.
• W2056570827 hasConcept C207001950 @default.
• W2056570827 hasConcept C25498285 @default.
• W2056570827 hasConcept C2780114680 @default.
• W2056570827 hasConcept C541997718 @default.
• W2056570827 hasConcept C55493867 @default.
• W2056570827 hasConcept C71924100 @default.
• W2056570827 hasConcept C86803240 @default.
• W2056570827 hasConcept C98274493 @default.
• W2056570827 hasConceptScore W2056570827C126322002 @default.
• W2056570827 hasConceptScore W2056570827C150903083 @default.
• W2056570827 hasConceptScore W2056570827C173396325 @default.
• W2056570827 hasConceptScore W2056570827C185592680 @default.
• W2056570827 hasConceptScore W2056570827C190283241 @default.
• W2056570827 hasConceptScore W2056570827C202751555 @default.
• W2056570827 hasConceptScore W2056570827C207001950 @default.
• W2056570827 hasConceptScore W2056570827C25498285 @default.
• W2056570827 hasConceptScore W2056570827C2780114680 @default.
• W2056570827 hasConceptScore W2056570827C541997718 @default.
• W2056570827 hasConceptScore W2056570827C55493867 @default.
• W2056570827 hasConceptScore W2056570827C71924100 @default.
• W2056570827 hasConceptScore W2056570827C86803240 @default.
• W2056570827 hasConceptScore W2056570827C98274493 @default.
• W2056570827 hasFunder F4320321001 @default.
• W2056570827 hasFunder F4320321605 @default.
• W2056570827 hasLocation W20565708271 @default.
• W2056570827 hasLocation W20565708272 @default.
• W2056570827 hasOpenAccess W2056570827 @default.
• W2056570827 hasPrimaryLocation W20565708271 @default.
• W2056570827 hasRelatedWork W1975240939 @default.
• W2056570827 hasRelatedWork W2029394706 @default.
• W2056570827 hasRelatedWork W2037001060 @default.
• W2056570827 hasRelatedWork W2077655479 @default.
• W2056570827 hasRelatedWork W2095198015 @default.

• next