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- W2056571314 abstract "Background Recently, differences in development of bacterial resistance were observed for macrolides with short and long elimination half life. Although one might speculate that this observation is to be explained by prolonged subinhibitory concentrations at the site of bacterial dwelling, the pharmacokinetic (PK) confirmation of this theory is missing. Thus we set out to compare PK of azithromycin and erythromycin in plasma, polymorphonuclear leukocytes (PML) and interstitial space fluid (ISF) of soft tissues." @default.
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- W2056571314 date "2010-11-01" @default.
- W2056571314 modified "2023-09-27" @default.
- W2056571314 title "Tissue pharmacokinetics of individual macrolides support observed differences in development of bacterial resistance" @default.
- W2056571314 doi "https://doi.org/10.1186/1471-2210-10-s1-a45" @default.
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