FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056571384> ?p ?o ?g. }

• W2056571384 abstract "Abstract In vitro work suggests that conjugated linoleic acid (CLA) isomers (c9,t11 and t10,c12) are cytotoxic to human breast cancer cells, however the mechanism remains unknown. Using human MCF‐7 breast cancer cells, we examined the effects of c9,t11 and t10,c12 CLA compared to oleic acid (OA), linoleic acid (LA), or untreated cells on cell membrane phospholipid composition, cell survival, and the insulin‐like growth factor‐I (IGF‐I) and the downstream insulin receptor substrate‐1 (IRS‐1). Both CLA isomers were incorporated into membrane phospholipids ( p < 0.05). Compared to untreated cells, c9,t11 or t10,c12 CLA significantly reduced the metabolic activity of IGF‐I stimulated MCF‐7 cells, increased lactate dehydrogenase (LDH) release, and decreased cellular concentrations of the IGF‐I receptor (IGF‐IR) and insulin receptor substrate‐1 ( p < 0.05). Incubation with t10,c12 CLA also reduced the levels of phosphorylated IGF‐1R. The effects on all of these measures were greater ( p < 0.05) for t10,c12 CLA compared to c9,t11 CLA. There were few differences between LA‐treated and c9,t11 CLA‐treated cells, whereas cellular metabolic activity, LDH release, and IGF‐IR concentrations differed between t10,c12 CLA‐treated and LA‐treated cells ( p < 0.05). OA stimulated growth compared to the untreated condition ( p < 0.05). In summary, this study demonstrated that the t10,c12 CLA isomer inhibits growth of MCF‐7 cells and suggested that this may be mediated through incorporation into cellular phospholipids and interference with the function of IGF‐I and related signaling proteins." @default.
• W2056571384 created "2016-06-24" @default.
• W2056571384 creator A5007880547 @default.
• W2056571384 creator A5086215918 @default.
• W2056571384 date "2009-03-06" @default.
• W2056571384 modified "2023-09-30" @default.
• W2056571384 title "Conjugated Linoleic Acid Decreases MCF-7 Human Breast Cancer Cell Growth and Insulin-Like Growth Factor-1 Receptor Levels" @default.
• W2056571384 cites W1523335221 @default.
• W2056571384 cites W1557488623 @default.
• W2056571384 cites W1891652867 @default.
• W2056571384 cites W1929680152 @default.
• W2056571384 cites W1957928270 @default.
• W2056571384 cites W1966760460 @default.
• W2056571384 cites W2000136948 @default.
• W2056571384 cites W2007905470 @default.
• W2056571384 cites W2013139454 @default.
• W2056571384 cites W2023205648 @default.
• W2056571384 cites W2023286320 @default.
• W2056571384 cites W2024988570 @default.
• W2056571384 cites W2034036867 @default.
• W2056571384 cites W2058617523 @default.
• W2056571384 cites W2059344419 @default.
• W2056571384 cites W2065019417 @default.
• W2056571384 cites W2068737811 @default.
• W2056571384 cites W2072144889 @default.
• W2056571384 cites W2085336350 @default.
• W2056571384 cites W2089389040 @default.
• W2056571384 cites W2089919345 @default.
• W2056571384 cites W2110730904 @default.
• W2056571384 cites W2111843196 @default.
• W2056571384 cites W2115421884 @default.
• W2056571384 cites W2129202730 @default.
• W2056571384 cites W2134557816 @default.
• W2056571384 cites W2141367941 @default.
• W2056571384 cites W2142896469 @default.
• W2056571384 cites W2144164082 @default.
• W2056571384 cites W2144710665 @default.
• W2056571384 cites W2150586678 @default.
• W2056571384 cites W2150604017 @default.
• W2056571384 cites W2150912425 @default.
• W2056571384 cites W2152316752 @default.
• W2056571384 cites W2152597496 @default.
• W2056571384 cites W2154817715 @default.
• W2056571384 cites W2155563237 @default.
• W2056571384 cites W2157843823 @default.
• W2056571384 cites W2159632750 @default.
• W2056571384 cites W2166684046 @default.
• W2056571384 cites W2168526937 @default.
• W2056571384 cites W2340717438 @default.
• W2056571384 cites W2406234400 @default.
• W2056571384 cites W2413138283 @default.
• W2056571384 cites W62108804 @default.
• W2056571384 doi "https://doi.org/10.1007/s11745-009-3288-4" @default.
• W2056571384 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19266226" @default.
• W2056571384 hasPublicationYear "2009" @default.
• W2056571384 type Work @default.
• W2056571384 sameAs 2056571384 @default.
• W2056571384 citedByCount "40" @default.
• W2056571384 countsByYear W20565713842012 @default.
• W2056571384 countsByYear W20565713842013 @default.
• W2056571384 countsByYear W20565713842014 @default.
• W2056571384 countsByYear W20565713842015 @default.
• W2056571384 countsByYear W20565713842016 @default.
• W2056571384 countsByYear W20565713842017 @default.
• W2056571384 countsByYear W20565713842018 @default.
• W2056571384 countsByYear W20565713842021 @default.
• W2056571384 countsByYear W20565713842022 @default.
• W2056571384 crossrefType "journal-article" @default.
• W2056571384 hasAuthorship W2056571384A5007880547 @default.
• W2056571384 hasAuthorship W2056571384A5086215918 @default.
• W2056571384 hasConcept C109541995 @default.
• W2056571384 hasConcept C112446052 @default.
• W2056571384 hasConcept C121608353 @default.
• W2056571384 hasConcept C126322002 @default.
• W2056571384 hasConcept C134018914 @default.
• W2056571384 hasConcept C170493617 @default.
• W2056571384 hasConcept C185592680 @default.
• W2056571384 hasConcept C2777391703 @default.
• W2056571384 hasConcept C2778918659 @default.
• W2056571384 hasConcept C2779306644 @default.
• W2056571384 hasConcept C2779780233 @default.
• W2056571384 hasConcept C2780809830 @default.
• W2056571384 hasConcept C2994423619 @default.
• W2056571384 hasConcept C41625074 @default.
• W2056571384 hasConcept C543025807 @default.
• W2056571384 hasConcept C55493867 @default.
• W2056571384 hasConcept C62112901 @default.
• W2056571384 hasConcept C71924100 @default.
• W2056571384 hasConcept C86803240 @default.
• W2056571384 hasConcept C96232424 @default.
• W2056571384 hasConceptScore W2056571384C109541995 @default.
• W2056571384 hasConceptScore W2056571384C112446052 @default.
• W2056571384 hasConceptScore W2056571384C121608353 @default.
• W2056571384 hasConceptScore W2056571384C126322002 @default.
• W2056571384 hasConceptScore W2056571384C134018914 @default.
• W2056571384 hasConceptScore W2056571384C170493617 @default.
• W2056571384 hasConceptScore W2056571384C185592680 @default.
• W2056571384 hasConceptScore W2056571384C2777391703 @default.
• W2056571384 hasConceptScore W2056571384C2778918659 @default.
• W2056571384 hasConceptScore W2056571384C2779306644 @default.

• next