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• W2056572319 abstract "The effects of the β-adrenoceptor agonist, isoprenaline, on Ca2+ mobilization and inositol phosphate formation in parotid acinar cells were examined. Isoprenaline (2 μM) failed to increase cytosolic [Ca2+] in acinar cells, as measured by Fura-2 fluorescence, even in the presence of a phosphodiesterase inhibitor. Likewise, neither the 8-bromo nor the dibutyryl derivatives of cAMP (both at 2 mM concentration) increased [Ca2+]i. However, in confirmation of results previously published, a higher concentration of isoprenaline (200 μM) increased cytosolic [Ca2+]i of rat parotid acinar cells, from 104 ± 4 nM to 151 ± 18 nM. The increase in [Ca2+]i in response to isoprenaline, while transient in the absence of extracellular Ca2+, was sustained in Ca2+-containing medium. This isoprenaline-stimulated Ca2+ signal was more potently antagonized by phentolamine than by propranolol, suggesting that the higher concentration of isoprenaline activated α-adrenoceptors. Furthermore, the Ca2+ signal generated in response to the α-adrenoceptor agonist, phenylephrine, also was blocked by the same concentrations of propranolol necessary to block the effects of isoprenaline, suggesting that propranolol may block α-adrenoceptors under certain experimental conditions. The high concentration of (−)isoprenaline (200 μM) also increased inositol (1,4,5) trisphosphate and inositol (1,3,4) trisphosphate formation 45% within 30 s. Analogous to the increase in intracellular Ca2+, the formation of inositol phosphates stimulated by isoprenaline was more potently antagonized by the α-adrenoceptor antagonist, phentolamine, than by the β-adrenoceptor antagonist, propranolol, again suggesting that isoprenaline interacts with α-adrenoceptors on parotid cells. Thus, the effects of isoprenaline on [Ca2+]i do not appear to be mediated by cAMP. Instead, the results suggest that the previously reported effects of high concentrations of isoprenaline on inositol phosphate formation and Ca2+ mobilization can be attributed to activation of α-adrenoceptors. Therefore, the activation of exocytosis in the parotid acinar cell through β-adrenoceptors does not appear to involve changes in cellular Ca2+ metabolism." @default.
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• W2056572319 date "1989-11-01" @default.
• W2056572319 modified "2023-10-18" @default.
• W2056572319 title "Does β-adrenoceptor activation stimulate Ca2+ mobilization and inositol trisphosphate formation in parotid acinar cells?" @default.
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• W2056572319 doi "https://doi.org/10.1016/0143-4160(89)90013-4" @default.
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