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• W2056572369 abstract "Mice with defects in the Klotho gene exhibit multiple aging phenotypes including arteriosclerosis. We hypothesised that the G-395A polymorphism in the promoter region of the human Klotho gene may contribute to the prevalence of Essential Hypertension (EH). We investigate whether the G-395A polymorphism of Klotho is associated with EH in a population consisting of 215 patients with EH and 220 non-hypertensive subjects. We also tested whether a G/A substitution at the G-395A site affected the transcription level in vitro through the dual-luciferase reporter assay. Differences in the genotype distributions of the G-395A polymorphism between the EH and non-hypertension groups are statistically significant (P = 0.032). There are differential effects of age, gender and smoking status on the association of the G-395A polymorphism with EH; the G-395A polymorphism is significantly associated with EH in subjects over 60 years old, in females and in nonsmokers. A multiple logistic regression analysis indicated that the odds ratio for EH in the –395A allele carriers as compared with the control group was 0.593 (P= 0.024) after adjusting for current traditional risk factors. The dual-luciferase reporter assay revealed that the –395A carrier of a 498-bp DNA fragment (containing the G-395A site) upstream of the Klotho gene has higher relative luciferase activity than the –395G carrier. The G-395A polymorphism of the human Klotho gene is associated with EH and may be a potential regulatory site." @default.
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• W2056572369 date "2010-03-01" @default.
• W2056572369 modified "2023-09-30" @default.
• W2056572369 title "A potential regulatory single nucleotide polymorphism in the promoter of the Klotho gene may be associated with essential hypertension in the Chinese Han population" @default.
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• W2056572369 doi "https://doi.org/10.1016/j.cca.2009.12.004" @default.
• W2056572369 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20005218" @default.
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