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- W2056572401 abstract "Aim The goal of this work was to investigate the associations of genetic and environmental factors with gemcitabine disposition and toxicity from genomewide data using a novel information theoretic approach. Methods We utilized the information theoretic K-way interaction information (KWII) metric to detect gene–gene and gene–environment interactions associated with gemcitabine disposition and gemcitabine-induced neutropenia in genomic and clinical data from Japanese cancer patients. Results The information theoretic KWII analyses identified age and four genes – DMD, HEXDC, CNTN4, and ALOX5AP – to be associated with gemcitabine pharmacokinetics (PK). The rs4769060 single-nucleotide polymorphism in the ALOX5AP gene was associated with all PK parameters studied. For gemcitabine-induced neutropenia, multiple associations with long intergenic noncoding RNA regions were detected. Pathway analysis identified leukotriene and eoxin synthesis, platelet homeostasis, and L1CAM interactions as potential pathways associated with gemcitabine disposition. Conclusion The KWII analyses detected novel associations with gemcitabine PK and toxicity. These results could be used to inform future investigations involving gemcitabine efficacy in clinical settings." @default.
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- W2056572401 date "2014-01-01" @default.
- W2056572401 modified "2023-10-16" @default.
- W2056572401 title "Genetic factors associated with gemcitabine pharmacokinetics, disposition, and toxicity" @default.
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- W2056572401 doi "https://doi.org/10.1097/fpc.0000000000000016" @default.
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