FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056572597> ?p ?o ?g. }

• W2056572597 abstract "Abstract Backgroud The role of cyclooxygenase-2 ( COX-2 ) single nucleotide polymorphisms has mostly been studied in relation to advanced atherosclerosis, but little is known how they contribute to preclinical disease. In the present study we analyzed whether COX-2 gene variants associate independently with the early subclinical markers of atherosclerosis, carotid intima-media thickness and carotid artery distensibility in a population of young healthy Caucasian adults. Methods SNPs for association analysis were collected from the COX-2 gene and 5 kb up- and downstream of it. There were 19 SNPs available for analysis, four genotyped and fifteen imputed. Genotype data was available for 2442 individuals participating in the Cardiovascular Risk in Young Finns Study. Genotype imputation was performed using MACH 1.0 and HapMap II CEU (release 22) samples as reference. Association analysis was performed using linear regression with an additive model. PLINK was used for true genotyped SNPs and ProbABEL for imputed genotype dosages. False discovery rate was used to take into account multiple testing bias. Results Two of the COX-2 variants ( rs689470, rs689462 ) associated with distensibility (p = 0.005) under the linear regression additive model. After adjustment with gender, age, body mass index and smoking status, association between these SNPs and distensibility remained significant (p = 0.031). Subjects carrying the minor alleles had higher value of carotid artery distensibility compared to the major allele homozygotes. However, after correcting p-values for multiple testing bias using false discovery rate, association was lost. Another COX-2 variant rs4648261 associated with mean carotid intima-media thickness (p = 0.046) and maximal carotid intima-media thickness (p = 0.048) in the linear regression model. Subjects carrying the minor allele of rs4648261 had lower values of mean and maximal carotid intima-media thickness compared to subjects homozygote for major allele. After adjustments the associations were lost with both mean and maximal carotid intima-media thickness. Thus, no statistically significant associations of the studied COX-2 variants with carotid artery distensibility or carotid intima-media thickness were found. Conclusions Our results suggest that in a Finnish population, there are no significant associations between COX-2 variants and early atherosclerotic changes in young adulthood." @default.
• W2056572597 created "2016-06-24" @default.
• W2056572597 creator A5018425233 @default.
• W2056572597 creator A5022876944 @default.
• W2056572597 creator A5022989536 @default.
• W2056572597 creator A5040232521 @default.
• W2056572597 creator A5060131080 @default.
• W2056572597 creator A5060330584 @default.
• W2056572597 creator A5064118768 @default.
• W2056572597 creator A5070506336 @default.
• W2056572597 creator A5073029734 @default.
• W2056572597 creator A5079643400 @default.
• W2056572597 creator A5080259574 @default.
• W2056572597 creator A5081478760 @default.
• W2056572597 creator A5081986241 @default.
• W2056572597 creator A5083681046 @default.
• W2056572597 date "2012-07-02" @default.
• W2056572597 modified "2023-09-26" @default.
• W2056572597 title "No Association of nineteen COX-2 gene variants to preclinical markers of atherosclerosis The Cardiovascular Risk in Young Finns Study" @default.
• W2056572597 cites W1575487625 @default.
• W2056572597 cites W1964797510 @default.
• W2056572597 cites W1965314708 @default.
• W2056572597 cites W1972489899 @default.
• W2056572597 cites W1987031993 @default.
• W2056572597 cites W2011718504 @default.
• W2056572597 cites W2028129180 @default.
• W2056572597 cites W2032539718 @default.
• W2056572597 cites W2040202877 @default.
• W2056572597 cites W2049131636 @default.
• W2056572597 cites W2052704549 @default.
• W2056572597 cites W2058166641 @default.
• W2056572597 cites W2066851524 @default.
• W2056572597 cites W2084120431 @default.
• W2056572597 cites W2088036472 @default.
• W2056572597 cites W2119586206 @default.
• W2056572597 cites W2123921851 @default.
• W2056572597 cites W2130833596 @default.
• W2056572597 cites W2133591735 @default.
• W2056572597 cites W2138876955 @default.
• W2056572597 cites W2153458404 @default.
• W2056572597 cites W2154971149 @default.
• W2056572597 cites W2161633633 @default.
• W2056572597 cites W2165472661 @default.
• W2056572597 cites W2166501262 @default.
• W2056572597 cites W2169101670 @default.
• W2056572597 cites W2171271146 @default.
• W2056572597 cites W2171537806 @default.
• W2056572597 cites W2315613231 @default.
• W2056572597 doi "https://doi.org/10.1186/1471-2350-13-32" @default.
• W2056572597 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3388005" @default.
• W2056572597 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22551325" @default.
• W2056572597 hasPublicationYear "2012" @default.
• W2056572597 type Work @default.
• W2056572597 sameAs 2056572597 @default.
• W2056572597 citedByCount "4" @default.
• W2056572597 countsByYear W20565725972014 @default.
• W2056572597 countsByYear W20565725972015 @default.
• W2056572597 countsByYear W20565725972021 @default.
• W2056572597 crossrefType "journal-article" @default.
• W2056572597 hasAuthorship W2056572597A5018425233 @default.
• W2056572597 hasAuthorship W2056572597A5022876944 @default.
• W2056572597 hasAuthorship W2056572597A5022989536 @default.
• W2056572597 hasAuthorship W2056572597A5040232521 @default.
• W2056572597 hasAuthorship W2056572597A5060131080 @default.
• W2056572597 hasAuthorship W2056572597A5060330584 @default.
• W2056572597 hasAuthorship W2056572597A5064118768 @default.
• W2056572597 hasAuthorship W2056572597A5070506336 @default.
• W2056572597 hasAuthorship W2056572597A5073029734 @default.
• W2056572597 hasAuthorship W2056572597A5079643400 @default.
• W2056572597 hasAuthorship W2056572597A5080259574 @default.
• W2056572597 hasAuthorship W2056572597A5081478760 @default.
• W2056572597 hasAuthorship W2056572597A5081986241 @default.
• W2056572597 hasAuthorship W2056572597A5083681046 @default.
• W2056572597 hasBestOaLocation W20565725971 @default.
• W2056572597 hasConcept C104317684 @default.
• W2056572597 hasConcept C126322002 @default.
• W2056572597 hasConcept C135763542 @default.
• W2056572597 hasConcept C143998085 @default.
• W2056572597 hasConcept C153209595 @default.
• W2056572597 hasConcept C157410074 @default.
• W2056572597 hasConcept C177580304 @default.
• W2056572597 hasConcept C2908647359 @default.
• W2056572597 hasConcept C50382708 @default.
• W2056572597 hasConcept C54355233 @default.
• W2056572597 hasConcept C71924100 @default.
• W2056572597 hasConcept C86803240 @default.
• W2056572597 hasConcept C99454951 @default.
• W2056572597 hasConceptScore W2056572597C104317684 @default.
• W2056572597 hasConceptScore W2056572597C126322002 @default.
• W2056572597 hasConceptScore W2056572597C135763542 @default.
• W2056572597 hasConceptScore W2056572597C143998085 @default.
• W2056572597 hasConceptScore W2056572597C153209595 @default.
• W2056572597 hasConceptScore W2056572597C157410074 @default.
• W2056572597 hasConceptScore W2056572597C177580304 @default.
• W2056572597 hasConceptScore W2056572597C2908647359 @default.
• W2056572597 hasConceptScore W2056572597C50382708 @default.
• W2056572597 hasConceptScore W2056572597C54355233 @default.
• W2056572597 hasConceptScore W2056572597C71924100 @default.
• W2056572597 hasConceptScore W2056572597C86803240 @default.
• W2056572597 hasConceptScore W2056572597C99454951 @default.

• next