FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056573287> ?p ?o ?g. }

• W2056573287 endingPage "7" @default.
• W2056573287 startingPage "1" @default.
• W2056573287 abstract "The wild type E. coli lac operator is embedded in a 35 base-pair DNA sequence containing extensive 2-fold symmetry, suggesting a symmetric repressor operator complex. However, deviations from strict 2-fold symmetry occur at the central base-pair and at three additional base-pairs. Using an operator fragment binding analysis we have determined: (a) a relative contribution each pair provides to the lac repressor-lac operator DNA complex, (b) the operator DNA length necessary for maximum binding to lac repressor; and (c) the contribution of the several non-symmetric base in the wild-type operator to the binding affinity. Since lac repressor-lac operator DNA interaction is reduced upon binding of the gratuitous inducer, isopropyl-β-D-galactoside (IPTG), the same DNA fragment binding analysis was performed with the low affinity form of lac repressor. In the presence of inducer, the affinity for the left half site of the wild-type lac operator is reduced without significant reduction on the right half of the operator. Conversely, the anti-inducer orthonitrophenylfucoside (ONPF) which stabilizes the lac repressor-lac operator complex increases the binding affinity, particularly to the right half of the operator." @default.
• W2056573287 created "2016-06-24" @default.
• W2056573287 creator A5035981341 @default.
• W2056573287 creator A5054751436 @default.
• W2056573287 creator A5068704464 @default.
• W2056573287 date "1997-01-01" @default.
• W2056573287 modified "2023-09-29" @default.
• W2056573287 title "Escherichia coli lac repressor-lac operator interaction and the influence of allosteric effectors" @default.
• W2056573287 cites W1510818199 @default.
• W2056573287 cites W1516369506 @default.
• W2056573287 cites W1558188591 @default.
• W2056573287 cites W1575106399 @default.
• W2056573287 cites W1963870747 @default.
• W2056573287 cites W1965853090 @default.
• W2056573287 cites W1982521217 @default.
• W2056573287 cites W1996261926 @default.
• W2056573287 cites W2000215876 @default.
• W2056573287 cites W2002711098 @default.
• W2056573287 cites W2007684278 @default.
• W2056573287 cites W2009217296 @default.
• W2056573287 cites W2020586816 @default.
• W2056573287 cites W2032619610 @default.
• W2056573287 cites W2036305210 @default.
• W2056573287 cites W2050643839 @default.
• W2056573287 cites W2051836775 @default.
• W2056573287 cites W2064795151 @default.
• W2056573287 cites W2071070642 @default.
• W2056573287 cites W2072108216 @default.
• W2056573287 cites W2073874317 @default.
• W2056573287 cites W2075147973 @default.
• W2056573287 cites W2077539492 @default.
• W2056573287 cites W2077973930 @default.
• W2056573287 cites W2089617243 @default.
• W2056573287 cites W2105090013 @default.
• W2056573287 cites W2154577805 @default.
• W2056573287 cites W2320909563 @default.
• W2056573287 doi "https://doi.org/10.1006/jmbi.1996.0706" @default.
• W2056573287 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8995519" @default.
• W2056573287 hasPublicationYear "1997" @default.
• W2056573287 type Work @default.
• W2056573287 sameAs 2056573287 @default.
• W2056573287 citedByCount "25" @default.
• W2056573287 countsByYear W20565732872012 @default.
• W2056573287 countsByYear W20565732872015 @default.
• W2056573287 crossrefType "journal-article" @default.
• W2056573287 hasAuthorship W2056573287A5035981341 @default.
• W2056573287 hasAuthorship W2056573287A5054751436 @default.
• W2056573287 hasAuthorship W2056573287A5068704464 @default.
• W2056573287 hasBestOaLocation W20565732871 @default.
• W2056573287 hasConcept C104317684 @default.
• W2056573287 hasConcept C107824862 @default.
• W2056573287 hasConcept C113629113 @default.
• W2056573287 hasConcept C150194340 @default.
• W2056573287 hasConcept C158448853 @default.
• W2056573287 hasConcept C166342909 @default.
• W2056573287 hasConcept C17020691 @default.
• W2056573287 hasConcept C170344550 @default.
• W2056573287 hasConcept C181199279 @default.
• W2056573287 hasConcept C185581394 @default.
• W2056573287 hasConcept C185592680 @default.
• W2056573287 hasConcept C203075996 @default.
• W2056573287 hasConcept C2225953 @default.
• W2056573287 hasConcept C22744801 @default.
• W2056573287 hasConcept C54355233 @default.
• W2056573287 hasConcept C547475151 @default.
• W2056573287 hasConcept C552990157 @default.
• W2056573287 hasConcept C55493867 @default.
• W2056573287 hasConcept C71240020 @default.
• W2056573287 hasConcept C86803240 @default.
• W2056573287 hasConceptScore W2056573287C104317684 @default.
• W2056573287 hasConceptScore W2056573287C107824862 @default.
• W2056573287 hasConceptScore W2056573287C113629113 @default.
• W2056573287 hasConceptScore W2056573287C150194340 @default.
• W2056573287 hasConceptScore W2056573287C158448853 @default.
• W2056573287 hasConceptScore W2056573287C166342909 @default.
• W2056573287 hasConceptScore W2056573287C17020691 @default.
• W2056573287 hasConceptScore W2056573287C170344550 @default.
• W2056573287 hasConceptScore W2056573287C181199279 @default.
• W2056573287 hasConceptScore W2056573287C185581394 @default.
• W2056573287 hasConceptScore W2056573287C185592680 @default.
• W2056573287 hasConceptScore W2056573287C203075996 @default.
• W2056573287 hasConceptScore W2056573287C2225953 @default.
• W2056573287 hasConceptScore W2056573287C22744801 @default.
• W2056573287 hasConceptScore W2056573287C54355233 @default.
• W2056573287 hasConceptScore W2056573287C547475151 @default.
• W2056573287 hasConceptScore W2056573287C552990157 @default.
• W2056573287 hasConceptScore W2056573287C55493867 @default.
• W2056573287 hasConceptScore W2056573287C71240020 @default.
• W2056573287 hasConceptScore W2056573287C86803240 @default.
• W2056573287 hasIssue "1" @default.
• W2056573287 hasLocation W20565732871 @default.
• W2056573287 hasLocation W20565732872 @default.
• W2056573287 hasOpenAccess W2056573287 @default.
• W2056573287 hasPrimaryLocation W20565732871 @default.
• W2056573287 hasRelatedWork W1505031824 @default.
• W2056573287 hasRelatedWork W1670843076 @default.
• W2056573287 hasRelatedWork W1968719582 @default.
• W2056573287 hasRelatedWork W2009217296 @default.

• next