Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056576445> ?p ?o ?g. }
- W2056576445 endingPage "100" @default.
- W2056576445 startingPage "89" @default.
- W2056576445 abstract "Differentiation of sympathetic neurons is controlled by a group of transcription factors, including Phox2b, Ascl1, Hand2 and Gata3, induced by bone morphogenetic proteins (BMPs) in progenitors located in ganglion primordia at the dorsal aorta. Here, we address the function of the transcription factors AP-2β and AP-2α, expressed in migrating neural crest cells (NCC) and maintained in sympathetic progenitors and differentiated neurons. The elimination of both AP-2α and AP-2β results in the virtually complete absence of sympathetic and sensory ganglia due to apoptotic cell death of migrating NCC. In the AP-2β knockout only sympathetic ganglia (SG) are targeted, leading to a reduction in ganglion size by about 40%, which is also caused by apoptotic death of neural crest progenitors. The conditional double knockout of AP-2α and AP-2β in sympathetic progenitors and differentiated noradrenergic neurons results in a further decrease in neuron number, leading eventually to small sympathetic ganglion rudiments postnatally. The elimination of AP-2β also leads to the complete absence of noradrenergic neurons of the Locus coeruleus (LC). Whereas AP-2α/β transcription factors are in vivo not required for the onset or maintenance of noradrenergic differentiation, their essential survival functions are demonstrated for sympathetic progenitors and noradrenergic neurons." @default.
- W2056576445 created "2016-06-24" @default.
- W2056576445 creator A5011765667 @default.
- W2056576445 creator A5023847450 @default.
- W2056576445 creator A5025695200 @default.
- W2056576445 creator A5046719540 @default.
- W2056576445 creator A5052790628 @default.
- W2056576445 creator A5083642080 @default.
- W2056576445 date "2011-07-01" @default.
- W2056576445 modified "2023-09-27" @default.
- W2056576445 title "The transcription factors AP-2β and AP-2α are required for survival of sympathetic progenitors and differentiated sympathetic neurons" @default.
- W2056576445 cites W1547754184 @default.
- W2056576445 cites W1860599747 @default.
- W2056576445 cites W1920995666 @default.
- W2056576445 cites W1964079625 @default.
- W2056576445 cites W1972652514 @default.
- W2056576445 cites W1977074100 @default.
- W2056576445 cites W1989139670 @default.
- W2056576445 cites W1994323615 @default.
- W2056576445 cites W2000299259 @default.
- W2056576445 cites W2006045768 @default.
- W2056576445 cites W2007116888 @default.
- W2056576445 cites W2010441495 @default.
- W2056576445 cites W2012882344 @default.
- W2056576445 cites W2014279663 @default.
- W2056576445 cites W2018708826 @default.
- W2056576445 cites W2021052173 @default.
- W2056576445 cites W2022804978 @default.
- W2056576445 cites W2024304348 @default.
- W2056576445 cites W2025706036 @default.
- W2056576445 cites W2027030154 @default.
- W2056576445 cites W2029787649 @default.
- W2056576445 cites W2032277756 @default.
- W2056576445 cites W2037601306 @default.
- W2056576445 cites W2039639864 @default.
- W2056576445 cites W2043242796 @default.
- W2056576445 cites W2043659972 @default.
- W2056576445 cites W2049406851 @default.
- W2056576445 cites W2058849934 @default.
- W2056576445 cites W2059032864 @default.
- W2056576445 cites W2061512404 @default.
- W2056576445 cites W2062548336 @default.
- W2056576445 cites W2071492047 @default.
- W2056576445 cites W2071749575 @default.
- W2056576445 cites W2072558955 @default.
- W2056576445 cites W2073935838 @default.
- W2056576445 cites W2079584632 @default.
- W2056576445 cites W2083755346 @default.
- W2056576445 cites W2086465672 @default.
- W2056576445 cites W2089210135 @default.
- W2056576445 cites W2089471100 @default.
- W2056576445 cites W2090338864 @default.
- W2056576445 cites W2091230390 @default.
- W2056576445 cites W2097138658 @default.
- W2056576445 cites W2098533907 @default.
- W2056576445 cites W2101889725 @default.
- W2056576445 cites W2109649512 @default.
- W2056576445 cites W2118160713 @default.
- W2056576445 cites W2122069573 @default.
- W2056576445 cites W2123373545 @default.
- W2056576445 cites W2131193695 @default.
- W2056576445 cites W2133485052 @default.
- W2056576445 cites W2134517045 @default.
- W2056576445 cites W2136006230 @default.
- W2056576445 cites W2139110700 @default.
- W2056576445 cites W2147774449 @default.
- W2056576445 cites W2153811105 @default.
- W2056576445 cites W2156315150 @default.
- W2056576445 cites W2159996969 @default.
- W2056576445 cites W2163408738 @default.
- W2056576445 cites W2170822244 @default.
- W2056576445 cites W1995995297 @default.
- W2056576445 doi "https://doi.org/10.1016/j.ydbio.2011.04.011" @default.
- W2056576445 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21539825" @default.
- W2056576445 hasPublicationYear "2011" @default.
- W2056576445 type Work @default.
- W2056576445 sameAs 2056576445 @default.
- W2056576445 citedByCount "44" @default.
- W2056576445 countsByYear W20565764452012 @default.
- W2056576445 countsByYear W20565764452013 @default.
- W2056576445 countsByYear W20565764452014 @default.
- W2056576445 countsByYear W20565764452015 @default.
- W2056576445 countsByYear W20565764452016 @default.
- W2056576445 countsByYear W20565764452017 @default.
- W2056576445 countsByYear W20565764452018 @default.
- W2056576445 countsByYear W20565764452019 @default.
- W2056576445 countsByYear W20565764452020 @default.
- W2056576445 countsByYear W20565764452021 @default.
- W2056576445 countsByYear W20565764452022 @default.
- W2056576445 countsByYear W20565764452023 @default.
- W2056576445 crossrefType "journal-article" @default.
- W2056576445 hasAuthorship W2056576445A5011765667 @default.
- W2056576445 hasAuthorship W2056576445A5023847450 @default.
- W2056576445 hasAuthorship W2056576445A5025695200 @default.
- W2056576445 hasAuthorship W2056576445A5046719540 @default.
- W2056576445 hasAuthorship W2056576445A5052790628 @default.
- W2056576445 hasAuthorship W2056576445A5083642080 @default.
- W2056576445 hasBestOaLocation W20565764451 @default.