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- W2056577920 abstract "We investigated the influence of testosterone on binding to established small-cell lung cancer (SCLC) cell lines and were able to show specific high-affinity and low-capacity binding sites in some cell lines with a typical receptor size, using sucrose density gradient centrifugation. In addition, we demonstrated marked growth stimulation with testosterone and dehydrotestosterone using different androgen-receptor-positive small-cell lung cancer cell lines. This growth stimulation could be counteracted by the addition of anti-androgens like cyproterone acetate or flutamide. The presence of 5α-reductase activity, 17ß-hydroxysteroid-dehydrogenase and 3α-hydroxy-steroid-dehydrogenase activities could be demonstrated, suggesting testosterone metabolism of small-cell lung cancer cell lines." @default.
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- W2056577920 date "1989-04-15" @default.
- W2056577920 modified "2023-09-24" @default.
- W2056577920 title "Androgen receptors, androgen-dependent proliferation, and 5α-reductase activity of small-cell lung cancer cell lines" @default.
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- W2056577920 doi "https://doi.org/10.1002/ijc.2910430424" @default.
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