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- W2056578408 abstract "1 The effects of vecuronium (Org NC45), Org 7678 and Org 7684 were examined on twitches and tetani recorded from rat isolated diaphragms 2 Org 7678 and Org 7684 exhibited approximately one tenth of the neuromuscular blocking potency of vecuronium. 3 At concentrations producing equivalent amounts of twitch block, Org 7684 produced significantly less tetanic fade than did vecuronium or Org 7678. 4 In cut muscles both vecuronium and Org 7684 reduced the endplate current (e.p.c.) amplitude (Ie.p.c.), reduced e.p.c. decay time constant (ẗe.p.c.), and increased the e.p.c. train rundown. 5 The effects of vecuronium were not voltage-dependent and vecuronium did not change ẗnoise. 6 The effect of Org 7684 on Ie.p.c. and ẗe.p.c. became greater with hyperpolarization, but the effect on e.p.c. train rundown was not voltage-dependent. 7 It is concluded that both vecuronium and Org 7684 produce e.p.c. train rundown and tetanic fade by a prejunctional mechanism. However, whereas postjunctionally vecuronium blocks only the acetylcholine receptor, Org 7684 blocks both the receptor and its associated ion channel." @default.
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- W2056578408 date "1987-03-01" @default.
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- W2056578408 title "Examination of the mechanisms involved in tetanic fade produced by vecuronium and related analogues in the rat diaphragm" @default.
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- W2056578408 doi "https://doi.org/10.1111/j.1476-5381.1987.tb11200.x" @default.
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