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- W2056578627 abstract "Introduction. Recently, it was reported that cardiotomy suction blood contains high levels of S100β. Therefore, the reinfusion of suction blood may be responsible for the low predictive value of S100β for cognitive decline after cardiac surgery with cardiopulmonary bypass. Consequently, it is expected that off-pump cardiac surgery will result in a lower release of S100β. Methods. S100β was measured after induction of anesthesia, at closure of the chest, and 8 hours and 20 hours after admittance at the intensive care unit in 187 patients randomly assigned to off-pump or on-pump coronary artery bypass grafting. In addition, arterio-jugular S100β differences were estimated in a subset of 61 patients. In a minority of the off-pump procedures, cell-saver blood was returned to the patients. Results. Tabled 1Table 1.Off-PumpOn-PumpMean Difference (95% CI)Start0.06 (0.05)0.06 (0.04)0.01–0.005(0.02)Closure0.44 (0.31)1.52 (1.13)−1.08–1.33(−0.83)8 hours0.20 (0.11)0.21 (0.13)−0.01–0.05(0.03)20 hours0.19 (0.11)0.21 (0.12)−0.02–0.06(0.02) Open table in a new tab Tabled 1Table 2.Arterio-jugular Difference95% CIOff-pump:Start−0.01−0.02; 0.01Closure−0.02−0.04; −0.003On-pump:Start−0.004−0.01; 0.003Closure−0.05−0.09; −0.01Data are presented as mean (SD) (μg/L). Open table in a new tab Data are presented as mean (SD) (μg/L). Conclusions. Although these data support the hypothesis that return of cardiotomy suction blood may increase early S100 release, off-pump, surgery without return of suction blood does not result in lower S100 levels 8 and 20 hours after surgery. The insignificant arterio-jugular difference at the start of the procedure and the small but significant negative arterio-jugular difference at the end of surgery indicate release from the brain." @default.
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- W2056578627 date "2002-01-01" @default.
- W2056578627 modified "2023-09-26" @default.
- W2056578627 title "S100β in off-pump coronary artery bypass grafting (CABG): a comparison with conventional CABG" @default.
- W2056578627 doi "https://doi.org/10.1016/s0003-4975(01)03544-5" @default.
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