FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056579482> ?p ?o ?g. }

• W2056579482 endingPage "e45909" @default.
• W2056579482 startingPage "e45909" @default.
• W2056579482 abstract "Podosomes are dynamic actin-based structures found constitutively in cells of monocytic origin such as macrophages, dendritic cells and osteoclasts. They have been involved in osteoclast cell adhesion, motility and matrix degradation, and all these functions rely on the ability of podosomes to form supra-molecular structures called podosome belts or sealing zones on mineralized substrates. Podosomes contain two distinct domains, an actin-rich core enriched in actin polymerization regulators, surrounded by a ring of signaling and plaque molecules. The organization of podosome arrays into belts is linked to actin dynamics. Cofilin is an actin-severing protein that is known to regulate cytoskeleton architecture and cell migration. Cofilin is present in lamellipodia and invadopodia where it regulates actin polymerization. In this report, we show that cofilin is a novel component of the podosome belt, the mature osteoclast adhesion structure. Time-course analysis demonstrated that cofilin is activated during primary osteoclast differentiation, at the time of podosome belt assembly. Immunofluorescence studies reveal a localization of active cofilin in the podosome core structure, whereas phosphorylated, inactive cofilin is concentrated in the podosome cloud. Pharmacological studies unraveled the role of a specific cofilin phosphatase to achieve cofilin activation during osteoclast differentiation. We ruled out the implication of PP1/PP2A and PTEN in this process, and rather provided evidence for the involvement of SSH1. In summary, our data involve cofilin as a regulator of podosome organization that is activated during osteoclast differentiation by a RANKL-mediated signaling pathway targeting the SSH1 phosphatase." @default.
• W2056579482 created "2016-06-24" @default.
• W2056579482 creator A5002724106 @default.
• W2056579482 creator A5025485122 @default.
• W2056579482 creator A5033589027 @default.
• W2056579482 creator A5053492137 @default.
• W2056579482 date "2012-09-25" @default.
• W2056579482 modified "2023-10-13" @default.
• W2056579482 title "Cofilin Activation during Podosome Belt Formation in Osteoclasts" @default.
• W2056579482 cites W1484094963 @default.
• W2056579482 cites W1968757816 @default.
• W2056579482 cites W1976100793 @default.
• W2056579482 cites W1984046567 @default.
• W2056579482 cites W1988787904 @default.
• W2056579482 cites W1989478104 @default.
• W2056579482 cites W2003736664 @default.
• W2056579482 cites W2004296878 @default.
• W2056579482 cites W2005716633 @default.
• W2056579482 cites W2007925869 @default.
• W2056579482 cites W2008546340 @default.
• W2056579482 cites W2009277812 @default.
• W2056579482 cites W2009996200 @default.
• W2056579482 cites W2017423449 @default.
• W2056579482 cites W2026266643 @default.
• W2056579482 cites W2028497798 @default.
• W2056579482 cites W2039480921 @default.
• W2056579482 cites W2042945898 @default.
• W2056579482 cites W2049166174 @default.
• W2056579482 cites W2050494316 @default.
• W2056579482 cites W2051190059 @default.
• W2056579482 cites W2057196925 @default.
• W2056579482 cites W2057570836 @default.
• W2056579482 cites W2064143357 @default.
• W2056579482 cites W2076277189 @default.
• W2056579482 cites W2082024168 @default.
• W2056579482 cites W2093279875 @default.
• W2056579482 cites W2093397086 @default.
• W2056579482 cites W2098301459 @default.
• W2056579482 cites W2099925679 @default.
• W2056579482 cites W2106516212 @default.
• W2056579482 cites W2109577877 @default.
• W2056579482 cites W2112229259 @default.
• W2056579482 cites W2115836236 @default.
• W2056579482 cites W2117116688 @default.
• W2056579482 cites W2126838501 @default.
• W2056579482 cites W2130409834 @default.
• W2056579482 cites W2130441255 @default.
• W2056579482 cites W2142960464 @default.
• W2056579482 cites W2150016769 @default.
• W2056579482 cites W2151891480 @default.
• W2056579482 cites W2153218395 @default.
• W2056579482 cites W2157293287 @default.
• W2056579482 cites W2160358447 @default.
• W2056579482 cites W2168525527 @default.
• W2056579482 cites W2170770186 @default.
• W2056579482 doi "https://doi.org/10.1371/journal.pone.0045909" @default.
• W2056579482 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3457939" @default.
• W2056579482 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23049890" @default.
• W2056579482 hasPublicationYear "2012" @default.
• W2056579482 type Work @default.
• W2056579482 sameAs 2056579482 @default.
• W2056579482 citedByCount "30" @default.
• W2056579482 countsByYear W20565794822013 @default.
• W2056579482 countsByYear W20565794822014 @default.
• W2056579482 countsByYear W20565794822015 @default.
• W2056579482 countsByYear W20565794822016 @default.
• W2056579482 countsByYear W20565794822017 @default.
• W2056579482 countsByYear W20565794822018 @default.
• W2056579482 countsByYear W20565794822019 @default.
• W2056579482 countsByYear W20565794822020 @default.
• W2056579482 crossrefType "journal-article" @default.
• W2056579482 hasAuthorship W2056579482A5002724106 @default.
• W2056579482 hasAuthorship W2056579482A5025485122 @default.
• W2056579482 hasAuthorship W2056579482A5033589027 @default.
• W2056579482 hasAuthorship W2056579482A5053492137 @default.
• W2056579482 hasBestOaLocation W20565794821 @default.
• W2056579482 hasConcept C109185818 @default.
• W2056579482 hasConcept C121608353 @default.
• W2056579482 hasConcept C125705527 @default.
• W2056579482 hasConcept C137738243 @default.
• W2056579482 hasConcept C141073059 @default.
• W2056579482 hasConcept C142669718 @default.
• W2056579482 hasConcept C1491633281 @default.
• W2056579482 hasConcept C185592680 @default.
• W2056579482 hasConcept C200786668 @default.
• W2056579482 hasConcept C2776601116 @default.
• W2056579482 hasConcept C2993400109 @default.
• W2056579482 hasConcept C54355233 @default.
• W2056579482 hasConcept C55493867 @default.
• W2056579482 hasConcept C86803240 @default.
• W2056579482 hasConcept C95444343 @default.
• W2056579482 hasConcept C96232424 @default.
• W2056579482 hasConceptScore W2056579482C109185818 @default.
• W2056579482 hasConceptScore W2056579482C121608353 @default.
• W2056579482 hasConceptScore W2056579482C125705527 @default.
• W2056579482 hasConceptScore W2056579482C137738243 @default.
• W2056579482 hasConceptScore W2056579482C141073059 @default.
• W2056579482 hasConceptScore W2056579482C142669718 @default.

• next