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- W2056579702 abstract "The therapeutic potential of gene transfer into somatic cells is increasingly considered in human diseases. Strategies are conceived to treat some diseases in which the delivery of a gene product can counteract a pathological process. There are three types of disease that form the target of these new potential treatments. In the first place, inherited gene defects; secondly, cell deficiencies leading to a lack of a gene product controlling a life-critical physiological function and thirdly, acquired diseases of tumour and/or viral origin. Such therapeutic tools must be evaluated in terms of efficacy and safety. They also have to be improved with respect to their effects in the perspective of a viable therapy for patients. This goal requires a strategy based on progressive steps toward efficient and safe clinical applications. This review will first survey the history of gene transfer technology and then describe the tools which are mainly being studied at present and how they are being developed to obtain a significant improvement of function." @default.
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- W2056579702 date "1993-12-01" @default.
- W2056579702 modified "2023-10-03" @default.
- W2056579702 title "Gene transfer in situ and in cells for intracerebral transplantation" @default.
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- W2056579702 doi "https://doi.org/10.1016/s1044-5765(05)80017-x" @default.
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