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- W2056579820 abstract "A water-soluble PEG derivative having both amino and carboxylic acid side chains (PEG-AC) was synthesized and explored for its transcription- and transfection-enhancing activity. PEG-AC could be deposited onto the surface of DNA/polycation complexes to form a ternary complex with slightly negative surface potential. PEG-AC-coating on the plasmid/PEI complexes obviously enhanced their transcriptional activity, and 31-fold higher consumption of UTP was observed. Amphoteric PEG-AC would loosen the tightly compacted DNA/PEI complex and facilitate the approach of transcriptional factors. PEG-AC also evidently improved the transgene expression level on the cultured CHO cells." @default.
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- W2056579820 date "2006-03-24" @default.
- W2056579820 modified "2023-09-27" @default.
- W2056579820 title "Enhancement of Transcriptional Activity of DNA Complexes by Amphoteric PEG Derivative" @default.
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- W2056579820 doi "https://doi.org/10.1021/bm0504633" @default.
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