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• W2056580329 startingPage "119" @default.
• W2056580329 abstract "The neutralizing and protective effect of murine monoclonal antibody (MAb) 3C7 (IgG1) against Pseudomonas aeruginosa exotoxin A was examined in an experimental mouse model of infection with exotoxin A-producing strains. Treatment with MAb 3C7 blocked the reduction of functional elongation factor 2 (EF-2) in the liver of mice but could not clear the bacteria. Administration of gentamicin caused bacteria to be cleared but did not block reduction of hepatic EF-2 level. Treatment with either MAb 3C7 or gentamicin individually did not prolong time to death; however, the combined therapy with both MAb 3C7 and gentamicin cleared bacteria and blocked the reduction of hepatic EF-2 level, resulting in a significant increase in the survival rate of mice. These results suggest that anti-exotoxin A MAbs show effectiveness against pseudomonal infection caused by exotoxin A-producing strains." @default.
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• W2056580329 date "1993-01-01" @default.
• W2056580329 modified "2023-09-26" @default.
• W2056580329 title "Protective Activity of Anti-Exotoxin A Monoclonal Antibody against Mice Infected with Toxin-Producing Pseudomonas aeruginosa" @default.
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• W2056580329 doi "https://doi.org/10.1093/infdis/167.1.113" @default.
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