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• W2056580624 abstract "Abstract It was reported earlier that methylcobalamin (MeB‐12) plus K2PtCl6 or Na2PtCl6 under acidic conditions yields a single square planar Pt2+ species, MePtCl2‐ 3. A reaction between MeB‐12 and PtCl4 in H2O has now been shown to occur. Complete demethylation requires two equivalents of PtCl4 and MePtCl2‐ 3 is the principal product. In addition, a second Me‐Pt product has been detected and isolated. It has a Me/Pt ratio of 1.0, but it lacks the 260 nm absorption maximum of MePtCl2‐ 3 and it has a lower electrophoretic mobility at pH 4.5. The proton NMR spectrum of this product shows a typical triplet pattern, but the chemical shift of the center band and the spin coupling constant change with pH. Its NMR parameters suggest that this species is MePt(H2O)Cl1‐ 2 (pKa ca. 4.5). A linear bridged intermediate is proposed to account for the methylation products obtained from MeB‐12 and K2PtCl6 (or PtCl4) and the catalytic role of K2PtCl4. As part of a systematic study of Pt‐complex mutagenesis, we also report quantitative data on the cytotoxicity and mutagenicity of PtCl4 in two closely related Chinese hamster ovary lines, CHO‐S and CHO‐AUXB1. In CHO‐S cells PtCl4 induces forward mutations to 8‐azaguanine resistance/hypoxanthine‐guanine phosphoribosyl transferase locus (8‐AGR/HGPRT locus), but not to ouabain resistance (OUAR). It also induces the reversion of CHO AUXB1, a triple auxotroph. The mutagenic effects of PtCl4 in both CHO lines are dose dependent in the 5–30 μM concentration range." @default.
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• W2056580624 date "1979-01-01" @default.
• W2056580624 modified "2023-10-09" @default.
• W2056580624 title "Platinum tetrachloride: Mutagenicity and methylation with methylcobálamin" @default.
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• W2056580624 doi "https://doi.org/10.1080/10934527909374864" @default.
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