Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056580949> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2056580949 endingPage "1291" @default.
- W2056580949 startingPage "1290" @default.
- W2056580949 abstract "One of the main problems encountered thus far in the quest for an effective HIV-1 vaccine has been that injected immunogens—virus-derived proteins against which an immune response is sought—generally only elicit antibodies with a narrow breadth of HIV-1 neutralization (1). During chronic infection, however, ∼10 to 30% of individuals naturally develop highly efficient antibodies that can neutralize multiple HIV-1 viral strains. These broadly neutralizing antibodies (bNAbs) have provided a template for the design of immunogens aimed at eliciting similar antibodies upon vaccination. On page 1380 of this issue, McGuire et al. (2) show that immunogens derived from the viral envelope glycoprotein of HIV-1 preferentially activate B cells that produce only narrow neutralizing antibodies (nNAbs). This supersedes the activation of B cells that produce the desired bNAbs, when both are present in the same pool of cells and are exposed to the same immunogen, possibly explaining the inability of previous vaccine candidates to achieve protective immune responses. By modifying the immunogen, McGuire et al. show that this preferential activation can be reversed in favor of the desired B cells, offering exciting new promise for vaccine design." @default.
- W2056580949 created "2016-06-24" @default.
- W2056580949 creator A5005979779 @default.
- W2056580949 creator A5031748920 @default.
- W2056580949 date "2014-12-12" @default.
- W2056580949 modified "2023-09-28" @default.
- W2056580949 title "Expanding the breadth of an HIV-1 vaccine" @default.
- W2056580949 cites W1968375364 @default.
- W2056580949 cites W1979058462 @default.
- W2056580949 cites W1999483871 @default.
- W2056580949 cites W2000885937 @default.
- W2056580949 cites W2016364569 @default.
- W2056580949 cites W2052937459 @default.
- W2056580949 cites W2053720630 @default.
- W2056580949 cites W2074179519 @default.
- W2056580949 cites W2081313987 @default.
- W2056580949 cites W2096367542 @default.
- W2056580949 cites W2118274231 @default.
- W2056580949 cites W2125878189 @default.
- W2056580949 cites W2135151522 @default.
- W2056580949 cites W2171478268 @default.
- W2056580949 cites W4246504300 @default.
- W2056580949 doi "https://doi.org/10.1126/science.aaa2315" @default.
- W2056580949 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25504701" @default.
- W2056580949 hasPublicationYear "2014" @default.
- W2056580949 type Work @default.
- W2056580949 sameAs 2056580949 @default.
- W2056580949 citedByCount "0" @default.
- W2056580949 crossrefType "journal-article" @default.
- W2056580949 hasAuthorship W2056580949A5005979779 @default.
- W2056580949 hasAuthorship W2056580949A5031748920 @default.
- W2056580949 hasConcept C108625454 @default.
- W2056580949 hasConcept C14086860 @default.
- W2056580949 hasConcept C159047783 @default.
- W2056580949 hasConcept C159654299 @default.
- W2056580949 hasConcept C203014093 @default.
- W2056580949 hasConcept C22070199 @default.
- W2056580949 hasConcept C2522874641 @default.
- W2056580949 hasConcept C2778190748 @default.
- W2056580949 hasConcept C2779261636 @default.
- W2056580949 hasConcept C2779909307 @default.
- W2056580949 hasConcept C2780195530 @default.
- W2056580949 hasConcept C2909828532 @default.
- W2056580949 hasConcept C3013748606 @default.
- W2056580949 hasConcept C542903549 @default.
- W2056580949 hasConcept C54355233 @default.
- W2056580949 hasConcept C86803240 @default.
- W2056580949 hasConcept C8891405 @default.
- W2056580949 hasConceptScore W2056580949C108625454 @default.
- W2056580949 hasConceptScore W2056580949C14086860 @default.
- W2056580949 hasConceptScore W2056580949C159047783 @default.
- W2056580949 hasConceptScore W2056580949C159654299 @default.
- W2056580949 hasConceptScore W2056580949C203014093 @default.
- W2056580949 hasConceptScore W2056580949C22070199 @default.
- W2056580949 hasConceptScore W2056580949C2522874641 @default.
- W2056580949 hasConceptScore W2056580949C2778190748 @default.
- W2056580949 hasConceptScore W2056580949C2779261636 @default.
- W2056580949 hasConceptScore W2056580949C2779909307 @default.
- W2056580949 hasConceptScore W2056580949C2780195530 @default.
- W2056580949 hasConceptScore W2056580949C2909828532 @default.
- W2056580949 hasConceptScore W2056580949C3013748606 @default.
- W2056580949 hasConceptScore W2056580949C542903549 @default.
- W2056580949 hasConceptScore W2056580949C54355233 @default.
- W2056580949 hasConceptScore W2056580949C86803240 @default.
- W2056580949 hasConceptScore W2056580949C8891405 @default.
- W2056580949 hasIssue "6215" @default.
- W2056580949 hasLocation W20565809491 @default.
- W2056580949 hasLocation W20565809492 @default.
- W2056580949 hasOpenAccess W2056580949 @default.
- W2056580949 hasPrimaryLocation W20565809491 @default.
- W2056580949 hasRelatedWork W1974138678 @default.
- W2056580949 hasRelatedWork W1981728941 @default.
- W2056580949 hasRelatedWork W1985404641 @default.
- W2056580949 hasRelatedWork W2042835129 @default.
- W2056580949 hasRelatedWork W2043102346 @default.
- W2056580949 hasRelatedWork W2068473665 @default.
- W2056580949 hasRelatedWork W2162650424 @default.
- W2056580949 hasRelatedWork W2803694530 @default.
- W2056580949 hasRelatedWork W4313366079 @default.
- W2056580949 hasRelatedWork W47778078 @default.
- W2056580949 hasVolume "346" @default.
- W2056580949 isParatext "false" @default.
- W2056580949 isRetracted "false" @default.
- W2056580949 magId "2056580949" @default.
- W2056580949 workType "article" @default.