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- W2056583182 abstract "Tolerance to the hypothermic effect of ethanol (Et–OH) developed in male Wistar rats treated daily with 5 g/kg of 20 per cent ET–OH v/v i.g. for 6 days. On Day 6 Et–OH treatment was discontinued and the animals were divided into two groups injected into the nucleus accumbens septi (NAS), either with pGlu-His-Pro-NH2 (TRH) or saline. The peptide was injected via permanently implanted cannulae in doses of 10 or 30 mg in 0.5 ml on each side once daily. The effect of such treatment on the maintenance of Et–OH tolerance was assessed by measuring the temperature decrement in response to a challenge dose of Et–OH (5 g/kg i.p.) given on Day 10. It was found that in saline-treated rats the initial tolerance declined. TRH-injected groups exhibited constantly low response to hypothermic action of Et–OH. In a control experiment TRH was shown to have no effect on the body temperature after intra-accumbens application in Et–OH-naive rats." @default.
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- W2056583182 date "1988-03-01" @default.
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- W2056583182 title "Intra-Accumbens trh prolongs maintenance of tolerance to hypothermic effect of ethanol in rats" @default.
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- W2056583182 doi "https://doi.org/10.1002/hup.470030111" @default.
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