FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056583222> ?p ?o ?g. }

• W2056583222 endingPage "441" @default.
• W2056583222 startingPage "431" @default.
• W2056583222 abstract "The selective destruction of neuronal perikarya via intracerebral injections of kainic acid was used to elucidate the cellular location of four neurotransmitter-related enzymes in the substantia nigra (SN). Two weeks after intranigral injections of kainic acid, dopamine-sensitive adenylate cyclase, glutamic acid decar☐ylase (GAD), choline acetyltransferase (CAT) and acetylcholinesterase (AChE) were measured in the SN. Histological examination of the SN, and a reduction of striatal tyrosine hydroxylase (TH) activity by 94%, confirmed the extensive loss of neuronal cell bodies in the SN. Dopamine stimulation of adenylate cyclase was not reduced in the lesioned SN, supporting the view that dendritically-released dopamine can regulate cyclic AMP synthesis in afferent terminals to these dendrites. Nigral GAD activity was significantly reduced by the lesions, suggesting that there are GAD-containing perikarya in the SN. CAT activity was not affected by the kainic injections, indicating the absence of cholinergic perikarya in the SN. Nigral AChE activity was significantly decreased after kainic injections, thus confirming the presence of AChE within the nigral perikarya. The results suggest that dopamine-sensitive adenylate cyclase and CAT are located within afferents to the SN, while GAD and AChE are found, to some extent at least, in neuronal soma of the SN. The differential effects of kainic acid on these enzymes suggest that this compound may be a useful neurochemical tool with which to determine the cellular distribution of enzyme systems in the central nervous system." @default.
• W2056583222 created "2016-06-24" @default.
• W2056583222 creator A5034663097 @default.
• W2056583222 creator A5040825701 @default.
• W2056583222 creator A5072830866 @default.
• W2056583222 creator A5082776762 @default.
• W2056583222 creator A5091528420 @default.
• W2056583222 date "1978-06-01" @default.
• W2056583222 modified "2023-10-15" @default.
• W2056583222 title "The use of kainic acid in the localization of enzymes in the substantia nigra" @default.
• W2056583222 cites W1598732229 @default.
• W2056583222 cites W1775749144 @default.
• W2056583222 cites W1853026346 @default.
• W2056583222 cites W1964442944 @default.
• W2056583222 cites W1964453493 @default.
• W2056583222 cites W1965284281 @default.
• W2056583222 cites W1978322449 @default.
• W2056583222 cites W1993470377 @default.
• W2056583222 cites W2001711966 @default.
• W2056583222 cites W2002761255 @default.
• W2056583222 cites W2003146000 @default.
• W2056583222 cites W2014486882 @default.
• W2056583222 cites W2023694499 @default.
• W2056583222 cites W2025848245 @default.
• W2056583222 cites W2027486179 @default.
• W2056583222 cites W2030780054 @default.
• W2056583222 cites W2033678540 @default.
• W2056583222 cites W2034363136 @default.
• W2056583222 cites W2038441483 @default.
• W2056583222 cites W2039186134 @default.
• W2056583222 cites W2042007672 @default.
• W2056583222 cites W2045094409 @default.
• W2056583222 cites W2046360475 @default.
• W2056583222 cites W2049594913 @default.
• W2056583222 cites W2052263727 @default.
• W2056583222 cites W2052591577 @default.
• W2056583222 cites W2054160097 @default.
• W2056583222 cites W2058243579 @default.
• W2056583222 cites W2058720711 @default.
• W2056583222 cites W2067290431 @default.
• W2056583222 cites W2069676793 @default.
• W2056583222 cites W2070020128 @default.
• W2056583222 cites W2074870180 @default.
• W2056583222 cites W2083146600 @default.
• W2056583222 cites W2083474530 @default.
• W2056583222 cites W2085113049 @default.
• W2056583222 cites W2085622609 @default.
• W2056583222 cites W2092740942 @default.
• W2056583222 cites W2093352898 @default.
• W2056583222 cites W2106528665 @default.
• W2056583222 cites W2133168541 @default.
• W2056583222 cites W2151368240 @default.
• W2056583222 cites W4252714631 @default.
• W2056583222 doi "https://doi.org/10.1016/0006-8993(78)90485-7" @default.
• W2056583222 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27284" @default.
• W2056583222 hasPublicationYear "1978" @default.
• W2056583222 type Work @default.
• W2056583222 sameAs 2056583222 @default.
• W2056583222 citedByCount "53" @default.
• W2056583222 crossrefType "journal-article" @default.
• W2056583222 hasAuthorship W2056583222A5034663097 @default.
• W2056583222 hasAuthorship W2056583222A5040825701 @default.
• W2056583222 hasAuthorship W2056583222A5072830866 @default.
• W2056583222 hasAuthorship W2056583222A5082776762 @default.
• W2056583222 hasAuthorship W2056583222A5091528420 @default.
• W2056583222 hasConcept C126322002 @default.
• W2056583222 hasConcept C134018914 @default.
• W2056583222 hasConcept C137183658 @default.
• W2056583222 hasConcept C170493617 @default.
• W2056583222 hasConcept C181199279 @default.
• W2056583222 hasConcept C185592680 @default.
• W2056583222 hasConcept C2776108384 @default.
• W2056583222 hasConcept C2776355744 @default.
• W2056583222 hasConcept C2780062018 @default.
• W2056583222 hasConcept C2780069284 @default.
• W2056583222 hasConcept C2780938664 @default.
• W2056583222 hasConcept C513476851 @default.
• W2056583222 hasConcept C55493867 @default.
• W2056583222 hasConcept C61174792 @default.
• W2056583222 hasConcept C71924100 @default.
• W2056583222 hasConcept C86803240 @default.
• W2056583222 hasConceptScore W2056583222C126322002 @default.
• W2056583222 hasConceptScore W2056583222C134018914 @default.
• W2056583222 hasConceptScore W2056583222C137183658 @default.
• W2056583222 hasConceptScore W2056583222C170493617 @default.
• W2056583222 hasConceptScore W2056583222C181199279 @default.
• W2056583222 hasConceptScore W2056583222C185592680 @default.
• W2056583222 hasConceptScore W2056583222C2776108384 @default.
• W2056583222 hasConceptScore W2056583222C2776355744 @default.
• W2056583222 hasConceptScore W2056583222C2780062018 @default.
• W2056583222 hasConceptScore W2056583222C2780069284 @default.
• W2056583222 hasConceptScore W2056583222C2780938664 @default.
• W2056583222 hasConceptScore W2056583222C513476851 @default.
• W2056583222 hasConceptScore W2056583222C55493867 @default.
• W2056583222 hasConceptScore W2056583222C61174792 @default.
• W2056583222 hasConceptScore W2056583222C71924100 @default.
• W2056583222 hasConceptScore W2056583222C86803240 @default.
• W2056583222 hasIssue "2" @default.

• next