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- W2056583254 abstract "tetra-O-methylnordihydroguaiaretic acid is a derivative of a naturally-occurring lignan, nordihydroguaiaretic acid, that has previously been shown to inhibit various cancer types in vitro and in vivo. Additionally, nordihydroguaiaretic acid has been shown to have nephrotoxic effects in the rat. Here we show that tetra-O-methylnordihydroguaiaretic acid inhibits the growth of a number of tumor cell lines in vitro by inducing apoptosis in a non-schedule-dependent manner. Further, this compound inhibits the synthesis of DNA by melanoma cells and causes cell cycle arrest in G0/G1 and G2/M phases of the cell cycle. tetra-O-Methylnordihydroguaiaretic acid also inhibits the growth of both murine and human melanomas and human colon cancer in vivo without apparent hepatic or renal toxicity." @default.
- W2056583254 created "2016-06-24" @default.
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- W2056583254 date "2001-08-01" @default.
- W2056583254 modified "2023-10-14" @default.
- W2056583254 title "tetra-O-Methylnordihydroguaiaretic acid inhibits melanoma in vivo" @default.
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- W2056583254 doi "https://doi.org/10.1016/s0304-3835(01)00560-2" @default.
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