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- W2056583643 endingPage "330" @default.
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- W2056583643 abstract "Maternal separation/handling (MS/H) is an animal model of early life stress that causes profound neurochemical and behavioral alterations in pups that persist into adulthood. Many recent studies have used the MS/H model to study changes in drug effects in adulthood that are linked to behavioral treatments and stressors in the perinatal period. The drug effects focused on in this review are the reinforcing properties of the abused drugs, cocaine and alcohol. A striking finding is that variations in maternal separation and handling cause changes in ethanol and cocaine self-administration. Further, these changes indicate that various manipulations in the perinatal period can have long lasting effects of interest to biochemical pharmacologists. This article will review recent studies on ethanol and cocaine self-administration using the MS/H model and the neurochemical alterations that may play a role in the effects of MS/H on ethanol and cocaine self-administration. Studying the MS/H model can provide important clues into the vulnerability to drug abuse and perhaps identify a crucial window of opportunity for therapeutic intervention." @default.
- W2056583643 created "2016-06-24" @default.
- W2056583643 creator A5004391355 @default.
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- W2056583643 creator A5055283751 @default.
- W2056583643 creator A5073519693 @default.
- W2056583643 creator A5075537778 @default.
- W2056583643 date "2007-02-01" @default.
- W2056583643 modified "2023-09-29" @default.
- W2056583643 title "Maternal separation alters drug intake patterns in adulthood in rats" @default.
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