Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056584991> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2056584991 endingPage "157" @default.
- W2056584991 startingPage "151" @default.
- W2056584991 abstract "In the field of drug delivery systems, microparticles made of polymeric matrix appear as an attractive approach. The in vitro release kinetic profile is crucial information when developing new particulate formulations. These data are essential for batch to batch comparison, quality control as well as for anticipation of in vivo behavior to select the best formulation to go further in preclinical investigations. The methods available present common drawbacks such as the time- and compound-consumption that does not fit with formulation screening requirements in early development stages. In this study, a new microscale high throughput screening (HTS) method has been developed to investigate drug release kinetic from piroxicam-loaded polylactic acid (PLA) and polylactic-co-glycolic acid (PLGA) microparticles. The method is a sample- and separation-based method where separation is performed by filtration using 96-well micro filter plates. 96 experiments can therefore be performed on one plate in one time in a fully automated way and with a very low sample and particle consumption. The influence of different parameters controlling release profiles was also investigated using this technique. The HTS method gave the same release profile than the standard dialysis method. Shaking, particle concentration, and the nature of the release medium were found to be of influence. The HTS method appears as a reliable method to evaluate drug release from particles with smaller standard deviation and less consumption of material." @default.
- W2056584991 created "2016-06-24" @default.
- W2056584991 creator A5003426636 @default.
- W2056584991 creator A5014486326 @default.
- W2056584991 creator A5017577532 @default.
- W2056584991 creator A5069108772 @default.
- W2056584991 creator A5086119216 @default.
- W2056584991 date "2013-09-01" @default.
- W2056584991 modified "2023-10-18" @default.
- W2056584991 title "New high throughput screening method for drug release measurements" @default.
- W2056584991 cites W1900239988 @default.
- W2056584991 cites W1973509266 @default.
- W2056584991 cites W1993456710 @default.
- W2056584991 cites W2014564300 @default.
- W2056584991 cites W2017426942 @default.
- W2056584991 cites W2023015920 @default.
- W2056584991 cites W2047824475 @default.
- W2056584991 cites W2049595148 @default.
- W2056584991 cites W2071179480 @default.
- W2056584991 cites W2071504476 @default.
- W2056584991 cites W2074061676 @default.
- W2056584991 cites W2098069960 @default.
- W2056584991 cites W2126784856 @default.
- W2056584991 cites W2166454694 @default.
- W2056584991 cites W33235804 @default.
- W2056584991 cites W65985194 @default.
- W2056584991 cites W1980203040 @default.
- W2056584991 cites W2019796793 @default.
- W2056584991 doi "https://doi.org/10.1016/j.ejpb.2013.02.012" @default.
- W2056584991 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23958326" @default.
- W2056584991 hasPublicationYear "2013" @default.
- W2056584991 type Work @default.
- W2056584991 sameAs 2056584991 @default.
- W2056584991 citedByCount "5" @default.
- W2056584991 countsByYear W20565849912014 @default.
- W2056584991 countsByYear W20565849912015 @default.
- W2056584991 countsByYear W20565849912016 @default.
- W2056584991 countsByYear W20565849912017 @default.
- W2056584991 crossrefType "journal-article" @default.
- W2056584991 hasAuthorship W2056584991A5003426636 @default.
- W2056584991 hasAuthorship W2056584991A5014486326 @default.
- W2056584991 hasAuthorship W2056584991A5017577532 @default.
- W2056584991 hasAuthorship W2056584991A5069108772 @default.
- W2056584991 hasAuthorship W2056584991A5086119216 @default.
- W2056584991 hasConcept C136229726 @default.
- W2056584991 hasConcept C147789679 @default.
- W2056584991 hasConcept C155672457 @default.
- W2056584991 hasConcept C159985019 @default.
- W2056584991 hasConcept C171250308 @default.
- W2056584991 hasConcept C185592680 @default.
- W2056584991 hasConcept C187530423 @default.
- W2056584991 hasConcept C192562407 @default.
- W2056584991 hasConcept C2779820397 @default.
- W2056584991 hasConcept C2780165375 @default.
- W2056584991 hasConcept C2781162966 @default.
- W2056584991 hasConcept C43617362 @default.
- W2056584991 hasConcept C521977710 @default.
- W2056584991 hasConcept C71924100 @default.
- W2056584991 hasConceptScore W2056584991C136229726 @default.
- W2056584991 hasConceptScore W2056584991C147789679 @default.
- W2056584991 hasConceptScore W2056584991C155672457 @default.
- W2056584991 hasConceptScore W2056584991C159985019 @default.
- W2056584991 hasConceptScore W2056584991C171250308 @default.
- W2056584991 hasConceptScore W2056584991C185592680 @default.
- W2056584991 hasConceptScore W2056584991C187530423 @default.
- W2056584991 hasConceptScore W2056584991C192562407 @default.
- W2056584991 hasConceptScore W2056584991C2779820397 @default.
- W2056584991 hasConceptScore W2056584991C2780165375 @default.
- W2056584991 hasConceptScore W2056584991C2781162966 @default.
- W2056584991 hasConceptScore W2056584991C43617362 @default.
- W2056584991 hasConceptScore W2056584991C521977710 @default.
- W2056584991 hasConceptScore W2056584991C71924100 @default.
- W2056584991 hasIssue "1" @default.
- W2056584991 hasLocation W20565849911 @default.
- W2056584991 hasLocation W20565849912 @default.
- W2056584991 hasOpenAccess W2056584991 @default.
- W2056584991 hasPrimaryLocation W20565849911 @default.
- W2056584991 hasRelatedWork W1993507577 @default.
- W2056584991 hasRelatedWork W2046814154 @default.
- W2056584991 hasRelatedWork W2049803349 @default.
- W2056584991 hasRelatedWork W2160389058 @default.
- W2056584991 hasRelatedWork W2383729495 @default.
- W2056584991 hasRelatedWork W2402277805 @default.
- W2056584991 hasRelatedWork W3019069663 @default.
- W2056584991 hasRelatedWork W3043291659 @default.
- W2056584991 hasRelatedWork W3163350643 @default.
- W2056584991 hasRelatedWork W976752491 @default.
- W2056584991 hasVolume "85" @default.
- W2056584991 isParatext "false" @default.
- W2056584991 isRetracted "false" @default.
- W2056584991 magId "2056584991" @default.
- W2056584991 workType "article" @default.