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- W2056585385 abstract "Prion diseases differ from other amyloid-associated protein misfolding diseases (e.g. Alzheimer's) because they are naturally transmitted between individuals and involve spread of protein aggregation between tissues. Factors underlying these features of prion diseases are poorly understood. Of all protein misfolding disorders, only prion diseases involve the misfolding of a glycosylphosphatidylinositol (GPI)-anchored protein. To test whether GPI anchoring can modulate the propagation and spread of protein aggregates, a GPI-anchored version of the amyloidogenic yeast protein Sup35NM (Sup35GPI) was expressed in neuronal cells. Treatment of cells with Sup35NM fibrils induced the GPI anchor-dependent formation of self-propagating, detergent-insoluble, protease-resistant, prion-like aggregates of Sup35GPI. Live-cell imaging showed intercellular spread of Sup35GPI aggregation to involve contact between aggregate-positive and aggregate-negative cells and transfer of Sup35GPI from aggregate-positive cells. These data demonstrate GPI anchoring facilitates the propagation and spread of protein aggregation and thus may enhance the transmissibility and pathogenesis of prion diseases relative to other protein misfolding diseases." @default.
- W2056585385 created "2016-06-24" @default.
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- W2056585385 date "2010-01-07" @default.
- W2056585385 modified "2023-10-18" @default.
- W2056585385 title "GPI anchoring facilitates propagation and spread of misfolded Sup35 aggregates in mammalian cells" @default.
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- W2056585385 cites W1555041989 @default.
- W2056585385 cites W1592250997 @default.
- W2056585385 cites W1602326892 @default.
- W2056585385 cites W1928837524 @default.
- W2056585385 cites W1939575473 @default.
- W2056585385 cites W1963901715 @default.
- W2056585385 cites W1977588092 @default.
- W2056585385 cites W1978217169 @default.
- W2056585385 cites W1978959047 @default.
- W2056585385 cites W1980115442 @default.
- W2056585385 cites W1985705452 @default.
- W2056585385 cites W1988276706 @default.
- W2056585385 cites W1989172027 @default.
- W2056585385 cites W1989208474 @default.
- W2056585385 cites W1995496955 @default.
- W2056585385 cites W2000204824 @default.
- W2056585385 cites W2001306764 @default.
- W2056585385 cites W2006934202 @default.
- W2056585385 cites W2007264976 @default.
- W2056585385 cites W2008671832 @default.
- W2056585385 cites W2016829947 @default.
- W2056585385 cites W2028877565 @default.
- W2056585385 cites W2030072508 @default.
- W2056585385 cites W2032825857 @default.
- W2056585385 cites W2034170455 @default.
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- W2056585385 cites W2046445620 @default.
- W2056585385 cites W2046843922 @default.
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- W2056585385 cites W2071464655 @default.
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- W2056585385 doi "https://doi.org/10.1038/emboj.2009.392" @default.
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