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• W2056587175 startingPage "e50870" @default.
• W2056587175 abstract "MicroRNAs (miRNAs) play a pivotal role in plant development. The expression patterns of the miRNA genes significantly influence their regulatory activities. By utilizing small RNA (sRNA) high-throughput sequencing (HTS) data, the miRNA expression patterns were investigated in four organs (flowers, leaves, roots and seedlings) of Arabidopsis. Based on a set of criteria, dozens of organ-specific miRNAs were discovered. A dominant portion of the organ-specific miRNAs identified from the ARGONAUTE 4-enriched sRNA HTS libraries were highly expressed in flowers. Additionally, the expression of the precursors of the organ-specific miRNAs was analyzed. Degradome sequencing data-based approach was employed to identify the targets of the organ-specific miRNAs. The miRNA–target interactions were used for network construction. Subnetwork analysis unraveled some novel regulatory cascades, such as the feedback regulation mediated by miR161, the potential self-regulation of the genes miR172, miR396, miR398 and miR860, and the miR863-guided cleavage of the SERRATE transcript. Our bioinformatics survey expanded the organ-specific miRNA–target list in Arabidopsis, and could deepen the biological view of the miRNA expression and their regulatory roles." @default.
• W2056587175 created "2016-06-24" @default.
• W2056587175 creator A5026717316 @default.
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• W2056587175 date "2012-11-30" @default.
• W2056587175 modified "2023-10-16" @default.
• W2056587175 title "Expression-Based Functional Investigation of the Organ-Specific MicroRNAs in Arabidopsis" @default.
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• W2056587175 doi "https://doi.org/10.1371/journal.pone.0050870" @default.
• W2056587175 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3511311" @default.
• W2056587175 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23226412" @default.
• W2056587175 hasPublicationYear "2012" @default.
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