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- W2056588217 abstract "We investigated molecular crowding effects on the thermodynamic stability of Hoogsteen and Watson-Crick base pairs in an intramolecular duplex and triplex. The melting temperature (Tm) of Hoogsteen base pair formations in the triplex and the duplex increased 3.7°C and 3.2°C, respectively, by adding 20 wt% PEG 200. On the other hand, the Tm of Watson-Crick base pair formations in the triplex and the duplex decreased 5.7°C and 5.2°C, respectively. These results suggested that molecular crowding conditions generally stabilized and destabilized Hoogsteen and Watson-Crick base pairs, respectively, even in the different DNA structures." @default.
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- W2056588217 date "2007-11-01" @default.
- W2056588217 modified "2023-09-27" @default.
- W2056588217 title "Effects of cosolutes on the thermodynamic stability of parallel DNA duplex and triplex" @default.
- W2056588217 doi "https://doi.org/10.1093/nass/nrm084" @default.
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