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- W2056589418 abstract "The DNA minor groove is an attractive target for the design and development of molecules able to specifically recognize predetermined DNA sequences. The pyrrole-amide skeleton of distamycin A has been also used as DNA sequence selective vehicle for the delivery of alkylating functions to DNA targets. Selectivity for specific sequences may be of particular importance in affecting the activity of regulatory genes (oncogenes and tumor suppressor genes). Recent work on a number of hybrid compounds, in which known antitumor compounds or simple active moieties of known antitumor agents have been tethered to distamycin frame or hairpin polyamides derived from distamycin, is reviewed. The DNA alkylating and growth inhibition activities against several tumor cell lines are reported and discussed in terms of their structural differences in relation to both the number of N-methyl pyrrolic rings and the type of the alkylating unit tethered to the oligopyrrolic frame." @default.
- W2056589418 created "2016-06-24" @default.
- W2056589418 creator A5033429648 @default.
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- W2056589418 creator A5041567500 @default.
- W2056589418 creator A5063804577 @default.
- W2056589418 creator A5073570032 @default.
- W2056589418 date "2007-01-01" @default.
- W2056589418 modified "2023-10-12" @default.
- W2056589418 title "Hybrid molecules between distamycin A and active moieties of antitumor agents" @default.
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- W2056589418 doi "https://doi.org/10.1016/j.bmc.2006.07.004" @default.