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• W2056589434 abstract "The aim of this study was to evaluate the activity and toxicity of capecitabine as third-line treatment in patients with advanced renal cell carcinoma for whom immunotherapy had failed. Twenty-one patients with metastatic clear renal cell carcinoma were enrolled. Capecitabine was administered orally twice daily at a dosage of 2500 mg/m2 for 14 days, followed by 7 days of rest. The median number of administered cycles was five (1–13). One patient (4.8%) achieved a remission after eight treatment cycles. Stable disease was observed in nine patients (42.8%), whereas 11 progressed (52.4%). The estimated median time to progression was 3.6 months (confidence interval: 1.4 to 5.2). The estimated median overall survival was 7.2 months (confidence interval: 4.6 to 8.8). The regimen was well tolerated and no unexpected toxic effects were observed. Capecitabine as third-line treatment showed a favourable toxicity profile, but exhibited low activity in patients with advanced renal cell carcinoma after failing immunotherapy." @default.
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• W2056589434 date "2007-08-01" @default.
• W2056589434 modified "2023-10-07" @default.
• W2056589434 title "Capecitabine as third-line treatment in patients with metastatic renal cell carcinoma after failing immunotherapy" @default.
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• W2056589434 doi "https://doi.org/10.1097/cad.0b013e3280a02f17" @default.
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