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• W2056589483 abstract "Abstract Autism is a particularly complex disorder when considered from virtually any methodological framework, including the perspective of human genetics. We first present a review of the genetic analysis principles relevant for discussing autism genetics research. From this body of work we highlight results from three candidate genes, REELIN ( RELN ), SEROTONIN TRANSPORTER ( 5HTT ), and ENGRAILED 2 ( EN2 ) and discuss the relevant neuroscience, molecular genetics, and statistical results that suggest involvement of these genes in autism susceptibility. As will be shown, the statistical results from genetic analysis, when considered alone, are in apparent conflict across research groups. We use these three candidate genes to illustrate different problems in synthesizing results from non‐overlapping research groups examining the same problem. However, when basic genetic principles and results from other scientific disciplines are incorporated into a unified theoretical framework, at least some of the difficulties with interpreting results can be understood and potentially overcome as more data becomes available to the field of autism research. Integrating results from several scientific frameworks provides new hypotheses and alternative data collection strategies for future work." @default.
• W2056589483 created "2016-06-24" @default.
• W2056589483 creator A5010180174 @default.
• W2056589483 creator A5023075925 @default.
• W2056589483 creator A5055130575 @default.
• W2056589483 creator A5055976283 @default.
• W2056589483 date "2004-12-18" @default.
• W2056589483 modified "2023-09-26" @default.
• W2056589483 title "Three autism candidate genes: a synthesis of human genetic analysis with other disciplines" @default.
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