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• W2056589769 abstract "The present investigation is concerned with the synthesis of different acylated 1,2,4-triazole-3-acetates with the objective of discovering novel and potent anti-inflammatory agents. Structures of the synthesized compounds were elucidated by spectral and elemental analyses. The obtained compounds were evaluated for their anti-inflammatory activites as well as gastric ulcerogenic effects and acute toxicity. Results showed that 1-acylated-5-amino-1,2,4-triazole-3-acetates 3a–e showed higher anti-inflammatory activity than the corresponding 5-acylamino derivatives 4a–e in carageenan-induced rat paw edema test with low gastric ulcerogenicity compared with indomethacin. Furthermore, molecular modeling studies were performed in order to rationalize the obtained biological results." @default.
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• W2056589769 date "2009-01-01" @default.
• W2056589769 modified "2023-10-03" @default.
• W2056589769 title "Design, synthesis and molecular modeling study of acylated 1,2,4-triazole-3-acetates with potential anti-inflammatory activity" @default.
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• W2056589769 doi "https://doi.org/10.1016/j.ejmech.2008.03.017" @default.
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