Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056590667> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W2056590667 endingPage "329" @default.
- W2056590667 startingPage "322" @default.
- W2056590667 abstract "Ropivacaine is a new amino-amide local anesthetic whose anesthetic profile appears similar to that of bupivacaine. Moreover, in intact animals ropivacaine was reportedly less arrhythmogenic than bupivacaine. These experiments evaluated the cardiac transmembrane electrophysiologic effects of ropivacaine compared with those of lidocaine and bupivacaine in an isolated rabbit Purkinje fiberventricular muscle preparation. Only bupivacaine (3-5 micrograms/ml, 0.92-1.5 x 10(-5) m) significantly decreased Purkinje fiber maximum diastolic potential. Action potential amplitude and maximal rate of depolarization (Vmax) were significantly decreased by all agents in the following order: bupivacaine, ropivacaine, lidocaine. High concentrations of bupivacaine and ropivacaine caused premature depolarizations during phase 3 in some preparations. In addition, bupivacaine altered the action potential configuration by producing notching not seen with either ropivacaine or lidocaine. This may reflect effects caused by changes in Ca2+, K+, or electrotonic effects. Ropivacaine and bupivacaine (30 micrograms/ml, 9.2 x 10(-5) m) and lidocaine (100 micrograms/ml, 3.74 x 10(-4) m) caused Purkinje fiber inexcitability and Purkinje fiber-ventricular muscle conduction block. However, the duration of PF inexcitability following exposure to ropivacaine and lidocaine was significantly shorter than in bupivacaine-treated preparation. Duration of PF-VM conduction block also tended to be shorter for ropivacaine than bupivacaine, but significantly longer than lidocaine. In general, ropivacaine is less potent than bupivacaine but more potent than lidocaine in terms of its depressant effect on cardiac excitation and conduction." @default.
- W2056590667 created "2016-06-24" @default.
- W2056590667 creator A5038581225 @default.
- W2056590667 creator A5040879909 @default.
- W2056590667 date "1990-02-01" @default.
- W2056590667 modified "2023-10-03" @default.
- W2056590667 title "Cardiac Electrophysiologic Properties of Bupivacaine and Lidocaine Compared with Those of Ropivacaine, A New Amide Local Anesthetic" @default.
- W2056590667 doi "https://doi.org/10.1097/00000542-199002000-00019" @default.
- W2056590667 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2301764" @default.
- W2056590667 hasPublicationYear "1990" @default.
- W2056590667 type Work @default.
- W2056590667 sameAs 2056590667 @default.
- W2056590667 citedByCount "144" @default.
- W2056590667 countsByYear W20565906672012 @default.
- W2056590667 countsByYear W20565906672013 @default.
- W2056590667 countsByYear W20565906672015 @default.
- W2056590667 countsByYear W20565906672016 @default.
- W2056590667 countsByYear W20565906672017 @default.
- W2056590667 countsByYear W20565906672019 @default.
- W2056590667 countsByYear W20565906672020 @default.
- W2056590667 countsByYear W20565906672021 @default.
- W2056590667 countsByYear W20565906672022 @default.
- W2056590667 countsByYear W20565906672023 @default.
- W2056590667 crossrefType "journal-article" @default.
- W2056590667 hasAuthorship W2056590667A5038581225 @default.
- W2056590667 hasAuthorship W2056590667A5040879909 @default.
- W2056590667 hasBestOaLocation W20565906671 @default.
- W2056590667 hasConcept C126322002 @default.
- W2056590667 hasConcept C185263204 @default.
- W2056590667 hasConcept C2777463368 @default.
- W2056590667 hasConcept C2778994108 @default.
- W2056590667 hasConcept C2780149897 @default.
- W2056590667 hasConcept C2780269707 @default.
- W2056590667 hasConcept C2781328992 @default.
- W2056590667 hasConcept C42219234 @default.
- W2056590667 hasConcept C71924100 @default.
- W2056590667 hasConceptScore W2056590667C126322002 @default.
- W2056590667 hasConceptScore W2056590667C185263204 @default.
- W2056590667 hasConceptScore W2056590667C2777463368 @default.
- W2056590667 hasConceptScore W2056590667C2778994108 @default.
- W2056590667 hasConceptScore W2056590667C2780149897 @default.
- W2056590667 hasConceptScore W2056590667C2780269707 @default.
- W2056590667 hasConceptScore W2056590667C2781328992 @default.
- W2056590667 hasConceptScore W2056590667C42219234 @default.
- W2056590667 hasConceptScore W2056590667C71924100 @default.
- W2056590667 hasIssue "2" @default.
- W2056590667 hasLocation W20565906671 @default.
- W2056590667 hasLocation W20565906672 @default.
- W2056590667 hasOpenAccess W2056590667 @default.
- W2056590667 hasPrimaryLocation W20565906671 @default.
- W2056590667 hasRelatedWork W1974062125 @default.
- W2056590667 hasRelatedWork W2056590667 @default.
- W2056590667 hasRelatedWork W2160611829 @default.
- W2056590667 hasRelatedWork W2364263956 @default.
- W2056590667 hasRelatedWork W2364488343 @default.
- W2056590667 hasRelatedWork W2388539920 @default.
- W2056590667 hasRelatedWork W2409443654 @default.
- W2056590667 hasRelatedWork W4247450932 @default.
- W2056590667 hasRelatedWork W4247798936 @default.
- W2056590667 hasRelatedWork W4293756414 @default.
- W2056590667 hasVolume "72" @default.
- W2056590667 isParatext "false" @default.
- W2056590667 isRetracted "false" @default.
- W2056590667 magId "2056590667" @default.
- W2056590667 workType "article" @default.