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• W2056594232 startingPage "7795" @default.
• W2056594232 abstract "Little is known about cyclic AMP (cAMP) function in Mycobacterium tuberculosis, despite its ability to encode 15 adenylate cyclases and 10 cNMP-binding proteins. M. tuberculosis Rv3676, which we have designated CRP(Mt), is predicted to be a cAMP-dependent transcription factor. In this study, we characterized CRP(Mt)'s interactions with DNA and cAMP, using experimental and computational approaches. We used Gibbs sampling to define a CRP(Mt) DNA motif that resembles the cAMP receptor protein (CRP) binding motif model for Escherichia coli. CRP(Mt) binding sites were identified in a total of 73 promoter regions regulating 114 genes in the M. tuberculosis genome, which are being explored as a regulon. Specific CRP(Mt) binding caused DNA bending, and the substitution of highly conserved nucleotides in the binding site resulted in a complete loss of binding to CRP(Mt). cAMP enhanced CRP(Mt)'s ability to bind DNA and caused allosteric alterations in CRP(Mt) conformation. These results provide the first direct evidence for cAMP binding to a transcription factor in M. tuberculosis, suggesting a role for cAMP signal transduction in M. tuberculosis and implicating CRP(Mt) as a cAMP-responsive global regulator." @default.
• W2056594232 created "2016-06-24" @default.
• W2056594232 creator A5001688784 @default.
• W2056594232 creator A5070140192 @default.
• W2056594232 creator A5085966383 @default.
• W2056594232 date "2005-11-15" @default.
• W2056594232 modified "2023-10-18" @default.
• W2056594232 title "Characterization of <i>Mycobacterium tuberculosis</i> Rv3676 (CRP _Mt ), a Cyclic AMP Receptor Protein-Like DNA Binding Protein" @default.
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• W2056594232 doi "https://doi.org/10.1128/jb.187.22.7795-7804.2005" @default.
• W2056594232 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1280308" @default.
• W2056594232 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16267303" @default.
• W2056594232 hasPublicationYear "2005" @default.
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