FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056594254> ?p ?o ?g. }

• W2056594254 abstract "Among mammals for which there is a high sequence coverage, the whole genome assembly of the dog is unique in that it predicts a low number of protein-coding genes, ~19,000, compared to the over 20,000 reported for other mammalian species. Of particular interest are the more than 400 of genes annotated in primates and rodent genomes, but missing in dog.Using over 14,000 orthologous genes between human, chimpanzee, mouse rat and dog, we built multiple pairwise synteny maps to infer short orthologous intervals that were targeted for characterizing the canine missing genes. Based on gene prediction and a functionality test using the ratio of replacement to silent nucleotide substitution rates (d(N)/d(S)), we provide compelling structural and functional evidence for the identification of 232 new protein-coding genes in the canine genome and 69 gene losses, characterized as undetected gene or pseudogenes. Gene loss phyletic pattern analysis using ten species from chicken to human allowed us to characterize 28 canine-specific gene losses that have functional orthologs continuously from chicken or marsupials through human, and 10 genes that arose specifically in the evolutionary lineage leading to rodent and primates.This study demonstrates the central role of comparative genomics for refining gene catalogs and exploring the evolutionary history of gene repertoires, particularly as applied for the characterization of species-specific gene gains and losses." @default.
• W2056594254 created "2016-06-24" @default.
• W2056594254 creator A5003742829 @default.
• W2056594254 creator A5044266156 @default.
• W2056594254 creator A5045178497 @default.
• W2056594254 creator A5052194592 @default.
• W2056594254 creator A5054099357 @default.
• W2056594254 creator A5085031832 @default.
• W2056594254 creator A5089411123 @default.
• W2056594254 date "2009-02-04" @default.
• W2056594254 modified "2023-10-09" @default.
• W2056594254 title "Revisiting the missing protein-coding gene catalog of the domestic dog" @default.
• W2056594254 cites W1570627319 @default.
• W2056594254 cites W1767772592 @default.
• W2056594254 cites W1963590211 @default.
• W2056594254 cites W1964264557 @default.
• W2056594254 cites W1966794959 @default.
• W2056594254 cites W1972476431 @default.
• W2056594254 cites W1980548655 @default.
• W2056594254 cites W1986009232 @default.
• W2056594254 cites W1992532041 @default.
• W2056594254 cites W1997113958 @default.
• W2056594254 cites W2010562878 @default.
• W2056594254 cites W2035178674 @default.
• W2056594254 cites W2036503152 @default.
• W2056594254 cites W2047405351 @default.
• W2056594254 cites W2048102092 @default.
• W2056594254 cites W2048385877 @default.
• W2056594254 cites W2066173565 @default.
• W2056594254 cites W2071486470 @default.
• W2056594254 cites W2072550492 @default.
• W2056594254 cites W2081633257 @default.
• W2056594254 cites W2085161553 @default.
• W2056594254 cites W2091813165 @default.
• W2056594254 cites W2097040991 @default.
• W2056594254 cites W2097710447 @default.
• W2056594254 cites W2098937968 @default.
• W2056594254 cites W2099762535 @default.
• W2056594254 cites W2100668314 @default.
• W2056594254 cites W2102120094 @default.
• W2056594254 cites W2102225814 @default.
• W2056594254 cites W2107537542 @default.
• W2056594254 cites W2108787198 @default.
• W2056594254 cites W2114049512 @default.
• W2056594254 cites W2114611642 @default.
• W2056594254 cites W2116072809 @default.
• W2056594254 cites W2118930999 @default.
• W2056594254 cites W2120864016 @default.
• W2056594254 cites W2123911320 @default.
• W2056594254 cites W2125387590 @default.
• W2056594254 cites W2127608175 @default.
• W2056594254 cites W2131053764 @default.
• W2056594254 cites W2137823340 @default.
• W2056594254 cites W2138247507 @default.
• W2056594254 cites W2142045367 @default.
• W2056594254 cites W2142418779 @default.
• W2056594254 cites W2143420603 @default.
• W2056594254 cites W2146120203 @default.
• W2056594254 cites W2146453000 @default.
• W2056594254 cites W2149152197 @default.
• W2056594254 cites W2151464048 @default.
• W2056594254 cites W2152301430 @default.
• W2056594254 cites W2158117993 @default.
• W2056594254 cites W2162037355 @default.
• W2056594254 cites W2162356213 @default.
• W2056594254 cites W2162558393 @default.
• W2056594254 cites W2168909179 @default.
• W2056594254 cites W2170496993 @default.
• W2056594254 cites W2203216274 @default.
• W2056594254 cites W4207034695 @default.
• W2056594254 cites W4376848561 @default.
• W2056594254 cites W626692 @default.
• W2056594254 doi "https://doi.org/10.1186/1471-2164-10-62" @default.
• W2056594254 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2644713" @default.
• W2056594254 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19193219" @default.
• W2056594254 hasPublicationYear "2009" @default.
• W2056594254 type Work @default.
• W2056594254 sameAs 2056594254 @default.
• W2056594254 citedByCount "18" @default.
• W2056594254 countsByYear W20565942542012 @default.
• W2056594254 countsByYear W20565942542013 @default.
• W2056594254 countsByYear W20565942542014 @default.
• W2056594254 countsByYear W20565942542017 @default.
• W2056594254 countsByYear W20565942542019 @default.
• W2056594254 countsByYear W20565942542020 @default.
• W2056594254 countsByYear W20565942542022 @default.
• W2056594254 countsByYear W20565942542023 @default.
• W2056594254 crossrefType "journal-article" @default.
• W2056594254 hasAuthorship W2056594254A5003742829 @default.
• W2056594254 hasAuthorship W2056594254A5044266156 @default.
• W2056594254 hasAuthorship W2056594254A5045178497 @default.
• W2056594254 hasAuthorship W2056594254A5052194592 @default.
• W2056594254 hasAuthorship W2056594254A5054099357 @default.
• W2056594254 hasAuthorship W2056594254A5085031832 @default.
• W2056594254 hasAuthorship W2056594254A5089411123 @default.
• W2056594254 hasBestOaLocation W20565942541 @default.
• W2056594254 hasConcept C104317684 @default.
• W2056594254 hasConcept C105176652 @default.
• W2056594254 hasConcept C105565629 @default.
• W2056594254 hasConcept C141231307 @default.

• next