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• W2056594451 abstract "Growing interest in personalised medicine and targeted therapies is leading to an increase in the importance of subgroup analyses. If it is planned to view treatment comparisons in both a predefined subgroup and the full population as co‐primary analyses, it is important that the statistical analysis controls the familywise type I error rate. Spiessens and Debois (Cont. Clin. Trials, 2010, 31, 647–656) recently proposed an approach specific for this setting, which incorporates an assumption about the correlation based on the known sizes of the different groups, and showed that this is more powerful than generic multiple comparisons procedures such as the Bonferroni correction. If recruitment is slow relative to the length of time taken to observe the outcome, it may be efficient to conduct an interim analysis. In this paper, we propose a new method for an adaptive clinical trial with co‐primary analyses in a predefined subgroup and the full population based on the conditional error function principle. The methodology is generic in that we assume test statistics can be taken to be normally distributed rather than making any specific distributional assumptions about individual patient data. In a simulation study, we demonstrate that the new method is more powerful than previously suggested analysis strategies. Furthermore, we show how the method can be extended to situations when the selection is not based on the final but on an early outcome. We use a case study in a targeted therapy in oncology to illustrate the use of the proposed methodology with non‐normal outcomes. Copyright © 2012 John Wiley & Sons, Ltd." @default.
• W2056594451 created "2016-06-24" @default.
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• W2056594451 date "2012-08-03" @default.
• W2056594451 modified "2023-09-27" @default.
• W2056594451 title "A conditional error function approach for subgroup selection in adaptive clinical trials" @default.
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• W2056594451 doi "https://doi.org/10.1002/sim.5541" @default.
• W2056594451 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22865774" @default.
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