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• W2056594649 abstract "Less than a year has elapsed between the discovery of trans-acting small interfering RNAs (tasiRNAs) in plants and the elucidation of the major steps of the corresponding pathway. During tasiRNA biogenesis, polyadenylated RNAs transcribed from non–protein-coding TAS genes are cleaved by a microRNA (miRNA)–programmed RNA-induced silencing complex. In contrast to classical miRNA targets, RDR6 and SGS3 convert one of the TAS RNA cleavage products into double-stranded RNA, which is subsequently processed, in a phase determined by the initial miRNA cleavage site, by DICER-LIKE 4 to generate a 21-nucleotide tasiRNA population. tasiRNAs guide endogenous mRNA cleavage through the action of AGO1 or, perhaps in some cases, AGO7. Some of the tasiRNA targets probably regulate the juvenile-to-adult phase transition, but the roles of other tasiRNA targets remain to be determined." @default.
• W2056594649 created "2016-06-24" @default.
• W2056594649 creator A5060928703 @default.
• W2056594649 date "2005-09-06" @default.
• W2056594649 modified "2023-10-16" @default.
• W2056594649 title "MicroRNA-Dependent Trans-Acting siRNA Production" @default.
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• W2056594649 doi "https://doi.org/10.1126/stke.3002005pe43" @default.
• W2056594649 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16145017" @default.
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