Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056595051> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2056595051 abstract "Introduction Both oxidative stress and the inflammatory chemokine MCP-1 have been linked to the pathophysiology of certain mental illnesses such as psychosis. There are previous studies in rats and dogs suggesting that oxidative stress can cause cognitive impairment. Objectives To correlate oxidative stress and the chemokine MCP-1 levels with cognitive impairment in first episode psychosis. Methods 28 patients with first episode psychosis and 28 healthy controls matched by sex and age were included in the study, who were given a battery of neurocognitive tests and we determined their blood levels of lipid peroxidation (TBARS), nitric oxide, total antioxidant status (TAS), glutathione, activity of enzymes catalase (CAT), glutathione peroxidase (cGPx) and superoxide dismutase (SOD) and the inflammatory chemokine MCP-1. Results Healthy controls had better TAS than patients and increased activity of enzymes cGPx and CAT. We found a statistically significant negative relationship between levels of MCP-1 and working memory, attention and verbal memory. At higher levels of chemokines, worse cognitive functioning in these areas. Verbal memory was also negatively related, in a meaningful way, with nitric oxide levels in blood. Likewise, we found that higher levels of glutathione correlated with better scores on the 3 tests performed of verbal fluency. Conclusions In patients with a PEP, levels of certain markers of oxidative stress and inflammation are associated with poorer cognitive functioning." @default.
- W2056595051 created "2016-06-24" @default.
- W2056595051 creator A5018396133 @default.
- W2056595051 creator A5019489574 @default.
- W2056595051 creator A5025936012 @default.
- W2056595051 creator A5048696998 @default.
- W2056595051 creator A5064378634 @default.
- W2056595051 creator A5071263625 @default.
- W2056595051 creator A5071270982 @default.
- W2056595051 creator A5071392461 @default.
- W2056595051 creator A5071965273 @default.
- W2056595051 creator A5088490214 @default.
- W2056595051 date "2011-03-01" @default.
- W2056595051 modified "2023-10-01" @default.
- W2056595051 title "Oxidative stress, inflammation and cognitive impairment in first psychotic patients" @default.
- W2056595051 doi "https://doi.org/10.1016/s0924-9338(11)72134-4" @default.
- W2056595051 hasPublicationYear "2011" @default.
- W2056595051 type Work @default.
- W2056595051 sameAs 2056595051 @default.
- W2056595051 citedByCount "0" @default.
- W2056595051 crossrefType "journal-article" @default.
- W2056595051 hasAuthorship W2056595051A5018396133 @default.
- W2056595051 hasAuthorship W2056595051A5019489574 @default.
- W2056595051 hasAuthorship W2056595051A5025936012 @default.
- W2056595051 hasAuthorship W2056595051A5048696998 @default.
- W2056595051 hasAuthorship W2056595051A5064378634 @default.
- W2056595051 hasAuthorship W2056595051A5071263625 @default.
- W2056595051 hasAuthorship W2056595051A5071270982 @default.
- W2056595051 hasAuthorship W2056595051A5071392461 @default.
- W2056595051 hasAuthorship W2056595051A5071965273 @default.
- W2056595051 hasAuthorship W2056595051A5088490214 @default.
- W2056595051 hasConcept C118552586 @default.
- W2056595051 hasConcept C126322002 @default.
- W2056595051 hasConcept C15744967 @default.
- W2056595051 hasConcept C2775838275 @default.
- W2056595051 hasConcept C2776151105 @default.
- W2056595051 hasConcept C2778760513 @default.
- W2056595051 hasConcept C2779727114 @default.
- W2056595051 hasConcept C2780829032 @default.
- W2056595051 hasConcept C71924100 @default.
- W2056595051 hasConceptScore W2056595051C118552586 @default.
- W2056595051 hasConceptScore W2056595051C126322002 @default.
- W2056595051 hasConceptScore W2056595051C15744967 @default.
- W2056595051 hasConceptScore W2056595051C2775838275 @default.
- W2056595051 hasConceptScore W2056595051C2776151105 @default.
- W2056595051 hasConceptScore W2056595051C2778760513 @default.
- W2056595051 hasConceptScore W2056595051C2779727114 @default.
- W2056595051 hasConceptScore W2056595051C2780829032 @default.
- W2056595051 hasConceptScore W2056595051C71924100 @default.
- W2056595051 hasLocation W20565950511 @default.
- W2056595051 hasOpenAccess W2056595051 @default.
- W2056595051 hasPrimaryLocation W20565950511 @default.
- W2056595051 hasRelatedWork W1098509294 @default.
- W2056595051 hasRelatedWork W2037548885 @default.
- W2056595051 hasRelatedWork W2048877386 @default.
- W2056595051 hasRelatedWork W2051870629 @default.
- W2056595051 hasRelatedWork W2054998761 @default.
- W2056595051 hasRelatedWork W2060038783 @default.
- W2056595051 hasRelatedWork W2074593772 @default.
- W2056595051 hasRelatedWork W2131971539 @default.
- W2056595051 hasRelatedWork W2166929726 @default.
- W2056595051 hasRelatedWork W2331354346 @default.
- W2056595051 hasRelatedWork W2759487912 @default.
- W2056595051 hasRelatedWork W2766151660 @default.
- W2056595051 hasRelatedWork W2886271475 @default.
- W2056595051 hasRelatedWork W2902901520 @default.
- W2056595051 hasRelatedWork W2933763445 @default.
- W2056595051 hasRelatedWork W2964064976 @default.
- W2056595051 hasRelatedWork W2980091176 @default.
- W2056595051 hasRelatedWork W3021167563 @default.
- W2056595051 hasRelatedWork W3044280035 @default.
- W2056595051 hasRelatedWork W2181519918 @default.
- W2056595051 isParatext "false" @default.
- W2056595051 isRetracted "false" @default.
- W2056595051 magId "2056595051" @default.
- W2056595051 workType "article" @default.