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- W2056595664 abstract "Summary These experiments indicate that penicillin remains a remarkably effective antimicrobial agent for the repression of experimental peritonitis in dogs. Providing these conclusions may be transferred to humans, penicillin may remain a drug of considerable importance in the treatment of peritonitis of gastrointestinal origin. Because of its relatively low degree of toxicity, which permits administration of large quantities of the drug, penicillin still closely approximates an ideal antibiotic. These experiments also indicate that an animal without an omentum will withstand peritonitis poorly, even with the administration of a dose of penicillin which would save a significant number of animals in which the omentum had not been removed. These data emphasize the urgency of early surgical correction of abdominal conditions likely to lead to peritonitis, such as intestinal obstruction, appendicitis, and the like, in infants and young children who have not developed a satisfactory omentum, and in adults who have had their omentum resected or effectively removed by adhesions. Surgical removal of the primary lesion would seem to hold the only chance of survival under these circumstances." @default.
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- W2056595664 date "1961-01-01" @default.
- W2056595664 modified "2023-09-25" @default.
- W2056595664 title "Present effect of penicillin on experimental peritonitis in dogs" @default.
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- W2056595664 doi "https://doi.org/10.1016/s0022-4804(61)80038-3" @default.
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