Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056596263> ?p ?o ?g. }
- W2056596263 endingPage "R458" @default.
- W2056596263 startingPage "R449" @default.
- W2056596263 abstract "Chronic administration of anorexigenic substances to experimental animals by injections or continuous infusion typically produces either no effect or a transient reduction in food intake and body weight. Our aim here was to identify an intermittent dosing strategy for intraperitoneal infusion of peptide YY(3-36) [PYY(3-36)] that produces a sustained reduction in daily food intake and adiposity in diet-induced obese rats. Rats (665 ± 10 g body wt, 166 ± 7 g body fat) with intraperitoneal catheters tethered to infusion swivels had free access to a high-fat diet. Vehicle-treated rats ( n = 23) had relatively stable food intake, body weight, and adiposity during the 9-wk test period. None of 15 PYY(3-36) dosing regimens administered in succession to a second group of rats ( n = 22) produced a sustained 15–25% reduction in daily food intake for >5 days, although body weight and adiposity were reduced across the 9-wk period by 12% (594 ± 15 vs. 672 ± 15 g) and 43% (96 ± 7 vs. 169 ± 9 g), respectively. The declining inhibitory effect of PYY(3-36) on daily food intake when the interinfusion interval was ≥3 h appeared to be due in part to an increase in food intake between infusions. The declining inhibitory effect of PYY(3-36) on daily food intake when the interinfusion interval was < 3 h suggested possible receptor downregulation and tolerance to frequent PYY(3-36) administration; however, food intake significantly increased when PYY(3-36) treatments were discontinued for 1 day following apparent loss in treatment efficacies. Together, these results demonstrate the development of a potent homeostatic response to increase food intake when PYY(3-36) reduces food intake and energy reserves in diet-induced obese rats." @default.
- W2056596263 created "2016-06-24" @default.
- W2056596263 creator A5029208124 @default.
- W2056596263 creator A5042147358 @default.
- W2056596263 creator A5044446436 @default.
- W2056596263 creator A5055369601 @default.
- W2056596263 date "2008-08-01" @default.
- W2056596263 modified "2023-09-27" @default.
- W2056596263 title "Effects of different intermittent peptide YY (3-36) dosing strategies on food intake, body weight, and adiposity in diet-induced obese rats" @default.
- W2056596263 cites W1489925379 @default.
- W2056596263 cites W1508456959 @default.
- W2056596263 cites W1840455279 @default.
- W2056596263 cites W1913169251 @default.
- W2056596263 cites W1968196420 @default.
- W2056596263 cites W1973715912 @default.
- W2056596263 cites W1975715952 @default.
- W2056596263 cites W1986251904 @default.
- W2056596263 cites W1993278976 @default.
- W2056596263 cites W1995335629 @default.
- W2056596263 cites W1995660637 @default.
- W2056596263 cites W1999413356 @default.
- W2056596263 cites W2012729666 @default.
- W2056596263 cites W2013138426 @default.
- W2056596263 cites W2013665956 @default.
- W2056596263 cites W2015620358 @default.
- W2056596263 cites W2019131037 @default.
- W2056596263 cites W2024204570 @default.
- W2056596263 cites W2030831607 @default.
- W2056596263 cites W2046683256 @default.
- W2056596263 cites W2059716194 @default.
- W2056596263 cites W2067158969 @default.
- W2056596263 cites W2079539251 @default.
- W2056596263 cites W2082113374 @default.
- W2056596263 cites W2093948960 @default.
- W2056596263 cites W2103040277 @default.
- W2056596263 cites W2104400385 @default.
- W2056596263 cites W2106714479 @default.
- W2056596263 cites W2119277064 @default.
- W2056596263 cites W2127779389 @default.
- W2056596263 cites W2128406991 @default.
- W2056596263 cites W2155419918 @default.
- W2056596263 cites W2157748967 @default.
- W2056596263 cites W2167840664 @default.
- W2056596263 cites W2169116402 @default.
- W2056596263 cites W2240927073 @default.
- W2056596263 doi "https://doi.org/10.1152/ajpregu.00040.2008" @default.
- W2056596263 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2519932" @default.
- W2056596263 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18550871" @default.
- W2056596263 hasPublicationYear "2008" @default.
- W2056596263 type Work @default.
- W2056596263 sameAs 2056596263 @default.
- W2056596263 citedByCount "31" @default.
- W2056596263 countsByYear W20565962632012 @default.
- W2056596263 countsByYear W20565962632013 @default.
- W2056596263 countsByYear W20565962632014 @default.
- W2056596263 countsByYear W20565962632015 @default.
- W2056596263 countsByYear W20565962632016 @default.
- W2056596263 countsByYear W20565962632017 @default.
- W2056596263 countsByYear W20565962632018 @default.
- W2056596263 countsByYear W20565962632021 @default.
- W2056596263 countsByYear W20565962632022 @default.
- W2056596263 crossrefType "journal-article" @default.
- W2056596263 hasAuthorship W2056596263A5029208124 @default.
- W2056596263 hasAuthorship W2056596263A5042147358 @default.
- W2056596263 hasAuthorship W2056596263A5044446436 @default.
- W2056596263 hasAuthorship W2056596263A5055369601 @default.
- W2056596263 hasBestOaLocation W20565962632 @default.
- W2056596263 hasConcept C118303440 @default.
- W2056596263 hasConcept C126322002 @default.
- W2056596263 hasConcept C134018914 @default.
- W2056596263 hasConcept C147583825 @default.
- W2056596263 hasConcept C170493617 @default.
- W2056596263 hasConcept C2777288759 @default.
- W2056596263 hasConcept C2780796126 @default.
- W2056596263 hasConcept C3018685816 @default.
- W2056596263 hasConcept C511355011 @default.
- W2056596263 hasConcept C544821477 @default.
- W2056596263 hasConcept C71924100 @default.
- W2056596263 hasConcept C93984277 @default.
- W2056596263 hasConceptScore W2056596263C118303440 @default.
- W2056596263 hasConceptScore W2056596263C126322002 @default.
- W2056596263 hasConceptScore W2056596263C134018914 @default.
- W2056596263 hasConceptScore W2056596263C147583825 @default.
- W2056596263 hasConceptScore W2056596263C170493617 @default.
- W2056596263 hasConceptScore W2056596263C2777288759 @default.
- W2056596263 hasConceptScore W2056596263C2780796126 @default.
- W2056596263 hasConceptScore W2056596263C3018685816 @default.
- W2056596263 hasConceptScore W2056596263C511355011 @default.
- W2056596263 hasConceptScore W2056596263C544821477 @default.
- W2056596263 hasConceptScore W2056596263C71924100 @default.
- W2056596263 hasConceptScore W2056596263C93984277 @default.
- W2056596263 hasIssue "2" @default.
- W2056596263 hasLocation W20565962631 @default.
- W2056596263 hasLocation W20565962632 @default.
- W2056596263 hasLocation W20565962633 @default.
- W2056596263 hasLocation W20565962634 @default.
- W2056596263 hasOpenAccess W2056596263 @default.
- W2056596263 hasPrimaryLocation W20565962631 @default.