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- W2056596998 abstract "This work aims to analyze the influence of aminophylline in the pulmonary and hepatic uptake of 99mTc-methoxyisobutil isonitrile (99mTc-MIBI). 72 patients were studied and a myocardial perfusion (MPS) single photon emission computed tomography (SPECT) with 99mTc-MIBI was carried out after the administration of dipyridamole. According to the MPS, the patients were classified into 2 groups: Group A: 45 patients without myocardial ischemia and Group B: 27 with ischemia. Each group was divided into 2 subgroups according to whether they had (I) or had not (II) received intravenous aminophylline. The dipyridamole was administered for 4 minutes at a dose of 0.56 mg/kg. If the patients presented any complication, intravenous aminophylline was administered. At 30 minutes p.i., planar images were obtained during a scintigraphy in the interior projection after the injection of 99mTc-MIBI. The regions of interest in the heart, hepatic cupula, and most active area of the left lung were outlines and the activity rates were calculated: lung/heart (LHR) and liver/heart (LivHR). No statistically significant differences were observed in the uptake of 99mTc-MIBI between subgroups I and II. However, the LHR rates in both subgroups were significantly lower in the patients with normal myocardial perfusion than in the patients with ischemia: LHR group A1 vs B1: 0.32 ± 0.08 vs 0.36 ± 0.06, p = 0.03; group AII vs BII 0.31 ± 0.07 vs 0.35 ± 0.07, p = 0.01 respectively. In conclusion, the administration of aminophylline, after the infusion of dipyridamole for MPS, does not modify the pulmonary or hepatic uptake of 99mTc-MIBI El objetivo del trabajo es analizar la influencia de la aminofilina en la captación pulmonar y hepática de 99mTc-metoxi-isobutyl-isonitrilo (99mTc-MIBI). Se han estudiado 72 pacientes en los que se practicó tomogammagrafía (SPECT) de perfusión miocárdico (MPS) con 99mTc-MIBI tras la administración de dipiridamol. Según la MPS se clasificaron los pacientes en 2 grupos. Grupo A: 45 pacientes sin isquemia miocárdica y Grupo B: 27 pacientes con isquemia. Cada grupo fue dividido en 2 subgrupos según hubieran (I) o no (II) recibido aminofilina intravenosa. El dipiridamol se administró durante 4 min a una dosis de 0,56 mg/kg. Si los pacientes presentaban cualquier complicación se administraba aminofilina intravenosa. A los 20 min p.i. del 99mTc-MIBI se registró una gammagrafía planar en proyección anterior. Se delimitaron regiones de interés en corazón, cúpula hepática y la zona más activa del pulmón izquierdo y se calcularon los índices de actividad: pulmón/ corazón (LHR) e hígado/corazón (LivHR). No se observaron diferencias estadísticamente significativas en la captación de 99mTc-MIBI entre los subgrupos I y II. Sin embargo los índices LHR en ambos subgrupos fueron significativamente menores en los pacientes con perfusión miocárdica normal que en los pacientes con isquemia: LHR grupo AI vs BI: 0,32 ± 0,08 vs 0,36 ± 0,06, p = 0,03; grupo AII vs BII 0,31 ± 0,07 vs 0,35 ± 0,07, p = 0,02 respectivamente). En conclusión, la administración de aminofilina, tras la infusión de dipiridamol para MPS no modifica la captación pulmonar ni la hepática de 99mTc-MIBI." @default.
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- W2056596998 title "The effect of aminophylline administration on 99mTc-MIBI lung and liver uptake in patients with or without myocardial ischemia" @default.
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- W2056596998 doi "https://doi.org/10.1016/s0212-6982(00)71904-5" @default.
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