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- W2056598212 abstract "Glia outnumber neurons and are the most abundant cell type in the nervous system. Whereas neurons are the major carriers, transducers, and processors of information, glial cells, once considered mainly to play a passive supporting role, are now recognized for their active contributions to almost every aspect of nervous system development. Recently, insights from the invertebrate organism Drosophila melanogaster have advanced our knowledge of glial cell biology. In particular, findings on neuron-glia interactions via intrinsic and extrinsic mechanisms have shed light on the importance of glia during different stages of neuronal development. Here, we summarize recent advances in understanding the functions of Drosophila glia, which resemble their mammalian counterparts in morphology and function, neural stem-cell conversion, synapse formation, and developmental axon pruning. These discoveries reinforce the idea that glia are substantial players in the developing nervous system and further advance the understanding of mechanisms leading to neurodegeneration." @default.
- W2056598212 created "2016-06-24" @default.
- W2056598212 creator A5018463427 @default.
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- W2056598212 creator A5076435657 @default.
- W2056598212 creator A5082088810 @default.
- W2056598212 date "2014-07-11" @default.
- W2056598212 modified "2023-09-27" @default.
- W2056598212 title "Glial cells in neuronal development: recent advances and insights from Drosophila melanogaster" @default.
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- W2056598212 doi "https://doi.org/10.1007/s12264-014-1448-2" @default.
- W2056598212 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5562627" @default.
- W2056598212 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25015062" @default.
- W2056598212 hasPublicationYear "2014" @default.