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- W2056598304 abstract "Tuberculosis still remains a global health emergency, claiming 1.5 million lives in 2013. The bacterium responsible for this disease, Mycobacterium tuberculosis (M.tb), has successfully survived within hostile host environments, adapting to immune defence mechanisms, for centuries. This has resulted in a disease that is challenging to treat, requiring lengthy chemotherapy with multi-drug regimens. One explanation for this difficulty in eliminating M.tb bacilli in vivo is the disparate action of antimicrobials on heterogeneous populations of M.tb, where mycobacterial physiological state may influence drug efficacy. In order to develop improved drug combinations that effectively target diverse mycobacterial phenotypes, it is important to understand how such subpopulations of M.tb are formed during human infection. We review here the in vitro and in vivo systems used to model M.tb subpopulations that may persist during drug therapy, and offer aspirations for future research in this field." @default.
- W2056598304 created "2016-06-24" @default.
- W2056598304 creator A5025724060 @default.
- W2056598304 creator A5063141051 @default.
- W2056598304 creator A5089284228 @default.
- W2056598304 date "2015-03-01" @default.
- W2056598304 modified "2023-10-14" @default.
- W2056598304 title "Understanding anti-tuberculosis drug efficacy: rethinking bacterial populations and how we model them" @default.
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- W2056598304 doi "https://doi.org/10.1016/j.ijid.2014.11.028" @default.
- W2056598304 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25809760" @default.
- W2056598304 hasPublicationYear "2015" @default.
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