FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056598383> ?p ?o ?g. }

• W2056598383 endingPage "1345" @default.
• W2056598383 startingPage "1337" @default.
• W2056598383 abstract "Surfactants stabilize proteins through two major mechanisms: (1) their preferential location at nearby interfaces, in this way precluding protein adsorption; and/or (2) their association with protein into “complexes” that prevent proteins from interacting with surfaces as well as each other. However, selection of surfactants for protein stabilization currently is not typically made with benefit of any quantitative, predictive information to ensure that either mechanism will be enforced. We compared surface tension depression by poloxamer 188, polysorbate (PS) 80, and PS 20 in the presence and absence of lysozyme or a recombinant protein. The kinetic results were interpreted with reference to a mechanism for surfactant adsorption governed by the formation of a rate-limiting structural intermediate (i.e., an “activated complex”) composed of surfactant and protein. The presence of protein was seen to increase the rate of surfactant adsorption in relation to surfactant acting alone for the PSs, with very little change in kinetics owing to protein in the case of poloxamer 188. A simple thermodynamic analysis indicated the presence of protein caused a reduction in ΔG for the surfactant adsorption process, deriving entirely from a reduction in ΔH. Thus, protein likely accelerates the adsorption of these surfactants by disrupting their self-associations, increasing the concentration of surfactant monomers near the interface. © 2014 Wiley Periodicals, Inc. and the American Pharmacists Association." @default.
• W2056598383 created "2016-06-24" @default.
• W2056598383 creator A5009592677 @default.
• W2056598383 creator A5024284243 @default.
• W2056598383 creator A5057247304 @default.
• W2056598383 date "2014-05-01" @default.
• W2056598383 modified "2023-10-15" @default.
• W2056598383 title "Protein Effects on Surfactant Adsorption Suggest the Dominant Mode of Surfactant-Mediated Stabilization of Protein" @default.
• W2056598383 cites W1581858536 @default.
• W2056598383 cites W1919447586 @default.
• W2056598383 cites W1970275629 @default.
• W2056598383 cites W1973599082 @default.
• W2056598383 cites W1978295616 @default.
• W2056598383 cites W1983387292 @default.
• W2056598383 cites W1993610262 @default.
• W2056598383 cites W2011132895 @default.
• W2056598383 cites W2025187028 @default.
• W2056598383 cites W2037385269 @default.
• W2056598383 cites W2038993272 @default.
• W2056598383 cites W2046078275 @default.
• W2056598383 cites W2047125616 @default.
• W2056598383 cites W2048909233 @default.
• W2056598383 cites W2048981144 @default.
• W2056598383 cites W2053727980 @default.
• W2056598383 cites W2058792545 @default.
• W2056598383 cites W2072398283 @default.
• W2056598383 cites W2085811290 @default.
• W2056598383 cites W2134625581 @default.
• W2056598383 cites W2171352575 @default.
• W2056598383 cites W3023309306 @default.
• W2056598383 doi "https://doi.org/10.1002/jps.23908" @default.
• W2056598383 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24585710" @default.
• W2056598383 hasPublicationYear "2014" @default.
• W2056598383 type Work @default.
• W2056598383 sameAs 2056598383 @default.
• W2056598383 citedByCount "33" @default.
• W2056598383 countsByYear W20565983832014 @default.
• W2056598383 countsByYear W20565983832015 @default.
• W2056598383 countsByYear W20565983832016 @default.
• W2056598383 countsByYear W20565983832017 @default.
• W2056598383 countsByYear W20565983832018 @default.
• W2056598383 countsByYear W20565983832019 @default.
• W2056598383 countsByYear W20565983832020 @default.
• W2056598383 countsByYear W20565983832021 @default.
• W2056598383 countsByYear W20565983832022 @default.
• W2056598383 countsByYear W20565983832023 @default.
• W2056598383 crossrefType "journal-article" @default.
• W2056598383 hasAuthorship W2056598383A5009592677 @default.
• W2056598383 hasAuthorship W2056598383A5024284243 @default.
• W2056598383 hasAuthorship W2056598383A5057247304 @default.
• W2056598383 hasConcept C101335993 @default.
• W2056598383 hasConcept C121332964 @default.
• W2056598383 hasConcept C12554922 @default.
• W2056598383 hasConcept C127413603 @default.
• W2056598383 hasConcept C136238340 @default.
• W2056598383 hasConcept C148898269 @default.
• W2056598383 hasConcept C150394285 @default.
• W2056598383 hasConcept C15920480 @default.
• W2056598383 hasConcept C178790620 @default.
• W2056598383 hasConcept C185592680 @default.
• W2056598383 hasConcept C2776966407 @default.
• W2056598383 hasConcept C42360764 @default.
• W2056598383 hasConcept C43617362 @default.
• W2056598383 hasConcept C521977710 @default.
• W2056598383 hasConcept C55493867 @default.
• W2056598383 hasConcept C58226133 @default.
• W2056598383 hasConcept C62520636 @default.
• W2056598383 hasConcept C86803240 @default.
• W2056598383 hasConcept C88001094 @default.
• W2056598383 hasConcept C8892853 @default.
• W2056598383 hasConcept C97355855 @default.
• W2056598383 hasConceptScore W2056598383C101335993 @default.
• W2056598383 hasConceptScore W2056598383C121332964 @default.
• W2056598383 hasConceptScore W2056598383C12554922 @default.
• W2056598383 hasConceptScore W2056598383C127413603 @default.
• W2056598383 hasConceptScore W2056598383C136238340 @default.
• W2056598383 hasConceptScore W2056598383C148898269 @default.
• W2056598383 hasConceptScore W2056598383C150394285 @default.
• W2056598383 hasConceptScore W2056598383C15920480 @default.
• W2056598383 hasConceptScore W2056598383C178790620 @default.
• W2056598383 hasConceptScore W2056598383C185592680 @default.
• W2056598383 hasConceptScore W2056598383C2776966407 @default.
• W2056598383 hasConceptScore W2056598383C42360764 @default.
• W2056598383 hasConceptScore W2056598383C43617362 @default.
• W2056598383 hasConceptScore W2056598383C521977710 @default.
• W2056598383 hasConceptScore W2056598383C55493867 @default.
• W2056598383 hasConceptScore W2056598383C58226133 @default.
• W2056598383 hasConceptScore W2056598383C62520636 @default.
• W2056598383 hasConceptScore W2056598383C86803240 @default.
• W2056598383 hasConceptScore W2056598383C88001094 @default.
• W2056598383 hasConceptScore W2056598383C8892853 @default.
• W2056598383 hasConceptScore W2056598383C97355855 @default.
• W2056598383 hasIssue "5" @default.
• W2056598383 hasLocation W20565983831 @default.
• W2056598383 hasLocation W20565983832 @default.
• W2056598383 hasOpenAccess W2056598383 @default.
• W2056598383 hasPrimaryLocation W20565983831 @default.
• W2056598383 hasRelatedWork W1541765418 @default.

• next