FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056598586> ?p ?o ?g. }

• W2056598586 endingPage "e39682" @default.
• W2056598586 startingPage "e39682" @default.
• W2056598586 abstract "The epidermal growth factor receptor (EGFR), which regulates cell growth and survival, is integral to colon tumorigenesis. Lipid rafts play a role in regulating EGFR signaling, and docosahexaenoic acid (DHA) is known to perturb membrane domain organization through changes in lipid rafts. Therefore, we investigated the mechanistic link between EGFR function and DHA. Membrane incorporation of DHA into immortalized colonocytes altered the lateral organization of EGFR. DHA additionally increased EGFR phosphorylation but paradoxically suppressed downstream signaling. Assessment of the EGFR-Ras-ERK1/2 signaling cascade identified Ras GTP binding as the locus of the DHA-induced disruption of signal transduction. DHA also antagonized EGFR signaling capacity by increasing receptor internalization and degradation. DHA suppressed cell proliferation in an EGFR-dependent manner, but cell proliferation could be partially rescued by expression of constitutively active Ras. Feeding chronically-inflamed, carcinogen-injected C57BL/6 mice a fish oil containing diet enriched in DHA recapitulated the effects on the EGFR signaling axis observed in cell culture and additionally suppressed tumor formation. We conclude that DHA-induced alteration in both the lateral and subcellular localization of EGFR culminates in the suppression of EGFR downstream signal transduction, which has implications for the molecular basis of colon cancer prevention by DHA." @default.
• W2056598586 created "2016-06-24" @default.
• W2056598586 creator A5005745021 @default.
• W2056598586 creator A5019568866 @default.
• W2056598586 creator A5067325195 @default.
• W2056598586 date "2012-06-27" @default.
• W2056598586 modified "2023-10-16" @default.
• W2056598586 title "Alteration of EGFR Spatiotemporal Dynamics Suppresses Signal Transduction" @default.
• W2056598586 cites W1578779604 @default.
• W2056598586 cites W1942708165 @default.
• W2056598586 cites W1948870077 @default.
• W2056598586 cites W1954377392 @default.
• W2056598586 cites W1964269462 @default.
• W2056598586 cites W1964369824 @default.
• W2056598586 cites W1964480443 @default.
• W2056598586 cites W1969117282 @default.
• W2056598586 cites W1970347121 @default.
• W2056598586 cites W1971935872 @default.
• W2056598586 cites W1975345098 @default.
• W2056598586 cites W1976214932 @default.
• W2056598586 cites W1980735842 @default.
• W2056598586 cites W1985234259 @default.
• W2056598586 cites W1986812906 @default.
• W2056598586 cites W1991739477 @default.
• W2056598586 cites W1992468993 @default.
• W2056598586 cites W1996490956 @default.
• W2056598586 cites W2000739823 @default.
• W2056598586 cites W2003625629 @default.
• W2056598586 cites W2004313693 @default.
• W2056598586 cites W2004934664 @default.
• W2056598586 cites W2005192572 @default.
• W2056598586 cites W2005496035 @default.
• W2056598586 cites W2007649418 @default.
• W2056598586 cites W2013643452 @default.
• W2056598586 cites W2013898467 @default.
• W2056598586 cites W2016324935 @default.
• W2056598586 cites W2016851491 @default.
• W2056598586 cites W2017086844 @default.
• W2056598586 cites W2022840517 @default.
• W2056598586 cites W2026578933 @default.
• W2056598586 cites W2032190558 @default.
• W2056598586 cites W2034550393 @default.
• W2056598586 cites W2035697025 @default.
• W2056598586 cites W2039473434 @default.
• W2056598586 cites W2040578305 @default.
• W2056598586 cites W2043911313 @default.
• W2056598586 cites W2049848617 @default.
• W2056598586 cites W2053668040 @default.
• W2056598586 cites W2057811812 @default.
• W2056598586 cites W2067664793 @default.
• W2056598586 cites W2070903093 @default.
• W2056598586 cites W2073723168 @default.
• W2056598586 cites W2077366285 @default.
• W2056598586 cites W2079263497 @default.
• W2056598586 cites W2086127297 @default.
• W2056598586 cites W2086520150 @default.
• W2056598586 cites W2089641881 @default.
• W2056598586 cites W2098301486 @default.
• W2056598586 cites W2098741945 @default.
• W2056598586 cites W2100649229 @default.
• W2056598586 cites W2105763574 @default.
• W2056598586 cites W2108099675 @default.
• W2056598586 cites W2111989705 @default.
• W2056598586 cites W2112915535 @default.
• W2056598586 cites W2113009216 @default.
• W2056598586 cites W2118122802 @default.
• W2056598586 cites W2121719392 @default.
• W2056598586 cites W2121958456 @default.
• W2056598586 cites W2123206362 @default.
• W2056598586 cites W2125251546 @default.
• W2056598586 cites W2125644093 @default.
• W2056598586 cites W2130359297 @default.
• W2056598586 cites W2131242309 @default.
• W2056598586 cites W2133591242 @default.
• W2056598586 cites W2135371328 @default.
• W2056598586 cites W2136558879 @default.
• W2056598586 cites W2137513862 @default.
• W2056598586 cites W2140882265 @default.
• W2056598586 cites W2141262449 @default.
• W2056598586 cites W2141726287 @default.
• W2056598586 cites W2143891754 @default.
• W2056598586 cites W2144710665 @default.
• W2056598586 cites W2145215560 @default.
• W2056598586 cites W2145863228 @default.
• W2056598586 cites W2146559835 @default.
• W2056598586 cites W2156309714 @default.
• W2056598586 cites W2156614769 @default.
• W2056598586 cites W2157571295 @default.
• W2056598586 cites W2158603948 @default.
• W2056598586 cites W2158734599 @default.
• W2056598586 cites W2159506005 @default.
• W2056598586 cites W2162030013 @default.
• W2056598586 cites W2165643695 @default.
• W2056598586 cites W2165685835 @default.
• W2056598586 cites W2169625731 @default.
• W2056598586 cites W2171460643 @default.
• W2056598586 cites W2322423893 @default.
• W2056598586 cites W4244120980 @default.

• next