FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056598999> ?p ?o ?g. }

• W2056598999 endingPage "R75" @default.
• W2056598999 startingPage "R75" @default.
• W2056598999 abstract "Neuroendocrine deficiencies may affect recovery after aneurysmal subarachnoid hemorrhage (aSAH). Insulin like growth factor-I (IGF-I) regulates neuronal growth and apoptosis in ischemic stroke. Our study was designed to a) characterize the behavior of serum IGF-I and growth hormone (GH) in the acute and late phases after aSAH reflecting possible pituitary gland function and b) evaluate the association between IGF-I and morbidity assessed by Glasgow outcome scale (GOS) and health related quality of life (HRQoL) in patients with aSAH. In this prospective cohort study, patients with aSAH (n = 30) were compared to patients who underwent elective aneurysm surgery (n = 16). Serum GH and IGF-I concentrations were measured daily for five (controls) or seven (aSAH) days and at three months. GOS and 15d HRQoL was measured at three months. A mixed models method was used for testing between the groups. For factors possibly affecting HRQoL in aSAH patients, we constructed a Bayesian predicting model using a P-course Bayesian classifier. The mean IGF-I concentrations for days one to five were 8.1 ± 3.5 nmol/l in patients with aSAH and 11.2 ± 3.1 in the control group (P = 0.01). No corresponding difference was found at three months. Serum GH concentrations were similar in both patient groups. Severity of the aSAH did not affect serum IGF-I concentrations. Patients with GOS ≤ 4 had lower IGF-I concentrations and lower HRQoL than patients with GOS 5 (P = 0.02 and 0.003 respectively). The 15d HRQoL was 0.81 ± 0.16 in patients with aSAH and 0.86 ± 0.09 in control patients (P = 0.24). In the Bayesian model, the use of statins prior to aSAH, hyponatremia, high maximal sequential organ specific score (SOFAmax), and low cumulative IGF-I concentrations on days one to seven were associated with poor HRQoL (accuracy 89%, sensitivity 86%, and specificity 93%). IGF-I concentrations are low during acute aSAH, which may have an impact on morbidity. ClinicalTrials.gov Identifier NCT00614887" @default.
• W2056598999 created "2016-06-24" @default.
• W2056598999 creator A5016674131 @default.
• W2056598999 creator A5018719057 @default.
• W2056598999 creator A5022964147 @default.
• W2056598999 creator A5039334184 @default.
• W2056598999 creator A5041635274 @default.
• W2056598999 creator A5062065113 @default.
• W2056598999 creator A5063597374 @default.
• W2056598999 date "2010-01-01" @default.
• W2056598999 modified "2023-09-26" @default.
• W2056598999 title "Insulin like growth factor-I in acute subarachnoid hemorrhage: a prospective cohort study" @default.
• W2056598999 cites W1981496258 @default.
• W2056598999 cites W1982626336 @default.
• W2056598999 cites W1997329894 @default.
• W2056598999 cites W2006334422 @default.
• W2056598999 cites W2013740117 @default.
• W2056598999 cites W2015253115 @default.
• W2056598999 cites W2017722607 @default.
• W2056598999 cites W2019603030 @default.
• W2056598999 cites W2020947579 @default.
• W2056598999 cites W2023520406 @default.
• W2056598999 cites W2038972858 @default.
• W2056598999 cites W2044159488 @default.
• W2056598999 cites W2058868308 @default.
• W2056598999 cites W2060362514 @default.
• W2056598999 cites W2062524407 @default.
• W2056598999 cites W2070875655 @default.
• W2056598999 cites W2095029545 @default.
• W2056598999 cites W2108086940 @default.
• W2056598999 cites W2108224685 @default.
• W2056598999 cites W2109931368 @default.
• W2056598999 cites W2116291080 @default.
• W2056598999 cites W2121854592 @default.
• W2056598999 cites W2125896595 @default.
• W2056598999 cites W2127660984 @default.
• W2056598999 cites W2131327815 @default.
• W2056598999 cites W2138577756 @default.
• W2056598999 cites W2144567418 @default.
• W2056598999 cites W2145397058 @default.
• W2056598999 cites W2145884553 @default.
• W2056598999 cites W2155479770 @default.
• W2056598999 cites W2158755924 @default.
• W2056598999 cites W2163614729 @default.
• W2056598999 cites W2168973485 @default.
• W2056598999 doi "https://doi.org/10.1186/cc8988" @default.
• W2056598999 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2887198" @default.
• W2056598999 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20426845" @default.
• W2056598999 hasPublicationYear "2010" @default.
• W2056598999 type Work @default.
• W2056598999 sameAs 2056598999 @default.
• W2056598999 citedByCount "13" @default.
• W2056598999 countsByYear W20565989992012 @default.
• W2056598999 countsByYear W20565989992013 @default.
• W2056598999 countsByYear W20565989992014 @default.
• W2056598999 countsByYear W20565989992016 @default.
• W2056598999 countsByYear W20565989992021 @default.
• W2056598999 countsByYear W20565989992023 @default.
• W2056598999 crossrefType "journal-article" @default.
• W2056598999 hasAuthorship W2056598999A5016674131 @default.
• W2056598999 hasAuthorship W2056598999A5018719057 @default.
• W2056598999 hasAuthorship W2056598999A5022964147 @default.
• W2056598999 hasAuthorship W2056598999A5039334184 @default.
• W2056598999 hasAuthorship W2056598999A5041635274 @default.
• W2056598999 hasAuthorship W2056598999A5062065113 @default.
• W2056598999 hasAuthorship W2056598999A5063597374 @default.
• W2056598999 hasBestOaLocation W20565989991 @default.
• W2056598999 hasConcept C126322002 @default.
• W2056598999 hasConcept C170493617 @default.
• W2056598999 hasConcept C17624336 @default.
• W2056598999 hasConcept C188816634 @default.
• W2056598999 hasConcept C2775960820 @default.
• W2056598999 hasConcept C2777736543 @default.
• W2056598999 hasConcept C2777796830 @default.
• W2056598999 hasConcept C2780689927 @default.
• W2056598999 hasConcept C42219234 @default.
• W2056598999 hasConcept C71924100 @default.
• W2056598999 hasConcept C72563966 @default.
• W2056598999 hasConcept C90924648 @default.
• W2056598999 hasConceptScore W2056598999C126322002 @default.
• W2056598999 hasConceptScore W2056598999C170493617 @default.
• W2056598999 hasConceptScore W2056598999C17624336 @default.
• W2056598999 hasConceptScore W2056598999C188816634 @default.
• W2056598999 hasConceptScore W2056598999C2775960820 @default.
• W2056598999 hasConceptScore W2056598999C2777736543 @default.
• W2056598999 hasConceptScore W2056598999C2777796830 @default.
• W2056598999 hasConceptScore W2056598999C2780689927 @default.
• W2056598999 hasConceptScore W2056598999C42219234 @default.
• W2056598999 hasConceptScore W2056598999C71924100 @default.
• W2056598999 hasConceptScore W2056598999C72563966 @default.
• W2056598999 hasConceptScore W2056598999C90924648 @default.
• W2056598999 hasIssue "2" @default.
• W2056598999 hasLocation W20565989991 @default.
• W2056598999 hasLocation W20565989992 @default.
• W2056598999 hasLocation W20565989993 @default.
• W2056598999 hasLocation W20565989994 @default.
• W2056598999 hasOpenAccess W2056598999 @default.
• W2056598999 hasPrimaryLocation W20565989991 @default.

• next