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• W2056613008 startingPage "1455" @default.
• W2056613008 abstract "Breviscapine is a Traditional Chinese Medicine treating cardiovascular diseases by promoting blood circulation and removing blood stasis. The major active component of breviscapine has low aqueous solubility, poor chemical stability, short biological half-life and rapid elimination rate from the plasma. The use of a lipid emulsion formulation containing breviscapine might improve chemical stability, increase drug loading, exhibit sustained release profile. In the present study, we developed an optimized formulation and technological method for the preparation of sterile and stable breviscapine lipid emulsion (Bre-LE) for intravenous infusion. The average particle size, polydispersity index, zeta potential, stability constant (Ks) value and content of final product were (225.3±8.8) nm, 0.221±0.020, (−29.6±1.5) mV, (24.3±2.9)% and (94.5±0.6)% respectively (n=3). The results of in vitro release experiment suggest that lipid emulsion as breviscapine carrier showed a desirable sustained release profile. Dilution stability and long-term stability were also researched in the present paper. The results show the carrier could protect drug from degradation after dilution by phosphate buffered saline and fetal calf serum. And Bre-LE was stable for up to 6 months at room temperature storage condition. The biodistribution of drug in heart of mice increased dramatically after encapsulation into lipid emulsion which was beneficial to heart disease therapy." @default.
• W2056613008 created "2016-06-24" @default.
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• W2056613008 date "2010-01-01" @default.
• W2056613008 modified "2023-09-25" @default.
• W2056613008 title "Optimized Preparation, Characterization and Biodistribution in Heart of Breviscapine Lipid Emulsion" @default.
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• W2056613008 doi "https://doi.org/10.1248/cpb.58.1455" @default.
• W2056613008 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21048336" @default.
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