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• W2056621518 abstract "TLX1/HOX11 is an oncogenic transcription factor in human T-cell leukemia, however, the molecular basis for its transforming activity has remained elusive. The ALDH1A1 gene, whose product participates in retinoic acid synthesis, was previously identified as a TLX1-responsive gene. Here, we confirm regulation of ALDH1A1 transcription by TLX1 and show that ALDH1A1 can profoundly perturb murine hematopoiesis by promoting myeloid differentiation at the expense of lymphopoiesis. Together, these data demonstrate that ALDH1A1 plays a key role in normal hematopoiesis, and confirm ALDH1A1 as a TLX1 transcriptional target that may contribute to the ability of this homeoprotein to alter cell fate and induce tumor growth." @default.
• W2056621518 created "2016-06-24" @default.
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• W2056621518 creator A5047693522 @default.
• W2056621518 creator A5082916034 @default.
• W2056621518 date "2008-06-01" @default.
• W2056621518 modified "2023-10-16" @default.
• W2056621518 title "Overexpression of stem cell associated ALDH1A1, a target of the leukemogenic transcription factor TLX1/HOX11, inhibits lymphopoiesis and promotes myelopoiesis in murine hematopoietic progenitors" @default.
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• W2056621518 doi "https://doi.org/10.1016/j.leukres.2007.11.001" @default.
• W2056621518 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18082256" @default.
• W2056621518 hasPublicationYear "2008" @default.
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